Compare Depo-Testosterone vs. Androderm

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depo-Testosterone
(Testosterone Cypionate Injection)

Androderm
(Testosterone Patch)

Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.Treats low testosterone. The testosterone patch is a topical form of hormone replacement that doesn't affect people you come in contact with, but it can cause skin irritation so you have to rotate its position every night.
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Reviews & ratings
Button Group. All currently active
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4.010204081632653Depo-Testosterone
Reviews for Depo-Testosterone (Testosterone Cypionate Injection)
48%
of people say Depo-Testosterone (Testosterone Cypionate Injection) is worth it
31%
say it works well
17%
say it's a big hassle

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Side effects
Depo-TestosteroneAndroderm

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »

The Androderm FDA package insert doesn’t have numbers about how common side effects are.

More about Androderm side effects »
How it works
Depo-TestosteroneAndroderm
The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.The testosterone patch works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
Depo-TestosteroneAndroderm
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
Depo-TestosteroneAndroderm
  • Injection
  • Patch
Used for (click to learn more)
Depo-TestosteroneAndroderm
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
Depo-TestosteroneAndroderm
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Heart, liver or kidney disease
  • Inability to move
  • Cancer
      • Diabetes
      • On blood thinners
        Detailed Depo-Testosterone (Testosterone Cypionate Injection) risks & warnings »
        Coming soon.
        Pregnancy category
        Depo-TestosteroneAndroderm
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
        No specific kidneys and liver-related info.
        Sex
        • Can cause increased acne and changes in sex drive.
        • If you're a man taking Depo-Testosterone (Testosterone Cypionate Injection), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
        • The testosterone patch doesn't have to be removed when you're having sex or if you're showering or bathing.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • If you're taking Depo-Testosterone (Testosterone Cypionate Injection), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
        No specific weight-related info.
        Upsides and benefits
        Depo-TestosteroneAndroderm
        • A first-choice treatment for low testosterone in men and delayed puberty in boys.
        • Available in generic.
        • Only has to be given once every 2 to 4 weeks.
        • The shot can be done at home.
        • The testosterone patch doesn't have to be removed when you're having sex or if you're showering or bathing.
        • The testosterone patch prevents other people around you from coming in contact with testosterone, unlike other topical forms such as gels.
        • The testosterone patch only has to be placed once each night.
        Downsides and risks
        Depo-TestosteroneAndroderm
        • Only available as a shot.
        • Has to be given by someone else since it has to be injected into your buttocks.
        • Not available in generic.
        • You have to be careful to rotate the testosterone patch to a different part of your body each night.
        • Can cause skin irritation.
        • Has to be removed before you have an MRI.
        • The patch can become loose if you do heavy exercise or sweat a lot.
        Tips from our pharmacists for people taking the medication
        Depo-TestosteroneAndroderm
        • Your doctor will show you how to inject this correctly.
        • Can cause nausea, vomiting and headache.
        • Can cause increased acne and changes in sex drive.
        • Keep this medication locked up and away from children since it's a controlled substance.
        • Place the testosterone patch on a clean, dry area of your skin each night. Don't put it on your scrotum or a bony part of your body.
        • Change the area where you place the testosterone patch every night, and wait at least 7 days before you put in on the same site again.
        • Make sure the patch is attached to your skin, especially along the edges. If it loosens, smooth the edges and then the center of the patch with your finger to make sure it's attached completely.
        • If the patch falls off before noon, apply another patch. If it falls off after that, don't apply another patch until your regular time at night. Don't use tape to keep the patch attached.
        • Don't bathe or swim for at least 3 hours after you put a new patch on. Also, heavy exercise or lots of sweating can make your patch fall off.
        Learn more
        More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
        More about AndrodermSide effectsReviews & ratingsAlternativesFDA package insert