Compare Depo-Testosterone vs. Androgel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats low testosterone.

This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.

3.0/ 5 average rating with 100 reviewsforDepo-Testosterone
Treats low testosterone.

This testosterone gel is a convenient topical form of hormone replacement, but you have to be careful about it rubbing off on other people. Also it can be cheaper than alternatives.

Upsides
  • A first-choice treatment for low testosterone in men and delayed puberty in boys.
  • Available in generic.
  • Only has to be given once every 2 to 4 weeks.
  • The shot can be done at home.
  • You put it on like a lotion, so it's very easy to apply.
  • Available in generic, so it's cheaper than some alternatives.
Downsides
  • Only available as a shot.
  • Has to be given by someone else since it has to be injected into your buttocks.
  • You have to make sure that you cover the area where you place testosterone gel after it's dry, otherwise it can rub off on people.
  • You have to wait at least 2 hours before you shower or swim after putting on Testosterone gel, otherwise your body won't absorb the entire amount.
Used for
  • Low testosterone
  • Low testosterone
Dosage forms
  • Injection
  • Cream, gel, or ointment
Price
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Reviews
100 reviews so far
49%
saidit'sworth it
32%
saiditworked well
17%
saidit'sa big hassle

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Side effects
The Depo-Testosterone (Testosterone Cypionate Injection) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • PSA increased
    11%
  • Any adverse reaction
    11%
  • Emotional lability
    3%
  • Hypertension
    2%
  • Hematocrit or hemoglobin increased
    2%
  • Contact dermatitis
    2%
See more detailed side effects
Risks and risk factors
  • Breast tissue changes
    • Male
  • Changes in sex drive
    • Male
  • Inability to urinate
    • Enlarged prostate (benign prostatic hypertrophy)
  • Changes in sperm
    • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Swelling in the legs
    • Heart, liver or kidney disease
  • High calcium in the blood
    • Inability to move
    • Cancer
  • Liver disease
  • Changes in mood
  • Changes in blood sugar
    • Diabetes
  • Changes in blood thinning
    • On blood thinners
  • Blood clots
See more detailed risks and warnings
No information currently available