Compare Depo-Testosterone vs. Androgel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depo-Testosterone
(Testosterone Cypionate Injection)

Androgel
(Testosterone Gel)

Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.Treats low testosterone. This testosterone gel is a convenient topical form of hormone replacement, but you have to be careful about it rubbing off on other people. Also it can be cheaper than alternatives.
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Reviews & ratings
Filter group. All currently selected
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4.010204081632653Depo-Testosterone
Reviews for Depo-Testosterone (Testosterone Cypionate Injection)
48%
of people (All ages) say Depo-Testosterone (Testosterone Cypionate Injection) is worth it
31%
say it works well
17%
say it's a big hassle
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Have you used Androgel (Testosterone Gel)?
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Side effects
Depo-TestosteroneAndrogel

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »

The Androgel FDA package insert doesn’t have numbers about how common side effects are.

More about Androgel side effects »
How it works
Depo-TestosteroneAndrogel
The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
Depo-TestosteroneAndrogel
Hormone replacement
Testosterone
Prescription only
Hormone replacement
Testosterone
Prescription only
Available as
Depo-TestosteroneAndrogel
  • Injection
  • Cream, gel, or ointment
Used for (click to learn more)
Depo-TestosteroneAndrogel
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
Depo-TestosteroneAndrogel
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Heart, liver or kidney disease
  • Inability to move
  • Cancer
      • Diabetes
      • On blood thinners
        Detailed Depo-Testosterone (Testosterone Cypionate Injection) risks & warnings »
        Coming soon.
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Kidneys and liver
        Depo-TestosteroneAndrogel
        • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
        No kidneys and liver related info.
        Upsides and benefits
        Depo-TestosteroneAndrogel
        • A first-choice treatment for low testosterone in men and delayed puberty in boys.
        • Available in generic.
        • Only has to be given once every 2 to 4 weeks.
        • The shot can be done at home.
        • You put it on like a lotion, so it's very easy to apply.
        • Available in generic, so it's cheaper than some alternatives.
        Downsides and risks
        Depo-TestosteroneAndrogel
        • Only available as a shot.
        • Has to be given by someone else since it has to be injected into your buttocks.
        • You have to make sure that you cover the area where you place testosterone gel after it's dry, otherwise it can rub off on people.
        • You have to wait at least 2 hours before you shower or swim after putting on Testosterone gel, otherwise your body won't absorb the entire amount.
        Tips from our pharmacists for people taking the medication
        Depo-TestosteroneAndrogel
        • Your doctor will show you how to inject this correctly.
        • Can cause nausea, vomiting and headache.
        • Can cause increased acne and changes in sex drive.
        • Keep this medication locked up and away from children since it's a controlled substance.
        • How to put it on: Don't put testosterone gel anywhere else except where you're taught by the doctor or pharmacist, usually the shoulders and upper arms. Don't put it around your genitals. Wash your hands with soap and water and dry them afterward. Cover the area with clothing as soon as it's dry so you don't spread it to other people.
        • Don't bathe or swim for at least 2 hours after you've put on testosterone gel so that it has time to absorb.
        • If you think you'll have skin-to-skin contact with someone else at the area where you've placed testosterone gel, wash that area with soap and water and dry. If someone else touches the area before you've washed it off, have them wash their skin with soap and water as soon as they can.
        Learn more
        More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Depo-Testosterone (Testosterone Cypionate Injection)?
        Worth itNot sureNot worth it
        More about AndrogelSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Androgel (Testosterone Gel)?
        Worth itNot sureNot worth it