Compare Depo Testosterone vs. Fortesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Depo-Testosterone
(Testosterone Cypionate Injection)

Fortesta
(Testosterone Gel)

Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.Treats low testosterone. This testosterone gel is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.06Depo Testosterone
Reviews for Depo-Testosterone (Testosterone Cypionate Injection)
49%
of people (All ages) say Depo-Testosterone (Testosterone Cypionate Injection) is worth it
32%
say it works well
17%
say it's a big hassle
100 reviews
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Side effects
Depo TestosteroneFortesta

The Depo Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo Testosterone side effects »
  • Skin reaction 16%
More Fortesta side effects »
How it works
Depo TestosteroneFortesta
The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
Depo TestosteroneFortesta
Prescription only
Prescription only
Available as
Depo TestosteroneFortesta
  • Injection
  • Cream, gel, or ointment
Used for
Depo TestosteroneFortesta
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
Depo TestosteroneFortesta
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Heart, liver or kidney disease
  • Inability to move
  • Cancer
      • Diabetes
      • On blood thinners
        Detailed Depo-Testosterone (Testosterone Cypionate Injection) risks & warnings »
        Coming soon.
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Kidneys and liver
        Depo TestosteroneFortesta
        • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
        No kidneys and liver related info.
        Upsides and benefits
        Depo TestosteroneFortesta
        • A first-choice treatment for low testosterone in men and delayed puberty in boys.
        • Available in generic.
        • Only has to be given once every 2 to 4 weeks.
        • The shot can be done at home.
        • You apply it to your thighs like a lotion.
        • Putting testosterone gel on your thights makes it less likely you'll transfer the medication to other people around you, compared to some other kinds of topical testosterone.
        Downsides and risks
        Depo TestosteroneFortesta
        • Only available as a shot.
        • Has to be given by someone else since it has to be injected into your buttocks.
        • Not available in generic form, so it can be more expensive.
        • You have to wait at least 2 hours after applying testosterone gel before you can swim or bathe, otherwise your body won't absorb the full amount of the medication.
        Tips from our pharmacists for people taking the medication
        Depo TestosteroneFortesta
        • Your doctor will show you how to inject this correctly.
        • Can cause nausea, vomiting and headache.
        • Can cause increased acne and changes in sex drive.
        • Keep this medication locked up and away from children since it's a controlled substance.
        • Prime testosterone gel first by pumping 8 times before you use a new bottle.
        • Don't swim or bathe for at least 2 hours after you apply testosterone gel.
        • Wash your hands with soap and water, and cover the area with clothing as soon as the gel is dry so you don't spread it to other people.
        • If you think you'll have skin-to-skin contact at the area where you've placed testosterone gel, wash that area with soap and water then dry.
        • Don't use testosterone gel anywhere besides your front and inner thighs.
        Learn more
        More about Depo TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Depo-Testosterone (Testosterone Cypionate Injection)?
        Worth itNot sureNot worth it
        More about FortestaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Fortesta (Testosterone Gel)?
        Worth itNot sureNot worth it