Compare Depo-Testosterone vs. Fortesta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats low testosterone.

This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.

3.0/ 5 average rating with 100 reviewsforDepo-Testosterone
Treats low testosterone.

This testosterone gel is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.

Upsides
  • A first-choice treatment for low testosterone in men and delayed puberty in boys.
  • Available in generic.
  • Only has to be given once every 2 to 4 weeks.
  • The shot can be done at home.
  • You apply it to your thighs like a lotion.
  • Putting testosterone gel on your thights makes it less likely you'll transfer the medication to other people around you, compared to some other kinds of topical testosterone.
Downsides
  • Only available as a shot.
  • Has to be given by someone else since it has to be injected into your buttocks.
  • Not available in generic form, so it can be more expensive.
  • You have to wait at least 2 hours after applying testosterone gel before you can swim or bathe, otherwise your body won't absorb the full amount of the medication.
Used for
  • Low testosterone
  • Low testosterone
Dosage forms
  • Injection
  • Cream, gel, or ointment
Price
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Reviews
100 reviews so far
49%
saidit'sworth it
32%
saiditworked well
17%
saidit'sa big hassle

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Side effects
The Depo-Testosterone (Testosterone Cypionate Injection) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Skin reaction
    16%
See more detailed side effects
Risks and risk factors
  • Breast tissue changes
    • Male
  • Changes in sex drive
    • Male
  • Inability to urinate
    • Enlarged prostate (benign prostatic hypertrophy)
  • Changes in sperm
    • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Swelling in the legs
    • Heart, liver or kidney disease
  • High calcium in the blood
    • Inability to move
    • Cancer
  • Liver disease
  • Changes in mood
  • Changes in blood sugar
    • Diabetes
  • Changes in blood thinning
    • On blood thinners
  • Blood clots
See more detailed risks and warnings
No information currently available