Compare desipramine vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Lidoderm (Lidocaine)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Treats nerve pain.

Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.

4.2/ 5 average rating with 18 reviewsforLidocaine
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
Used for
Dosage forms
  • Pill
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Price
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Reviews
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18 reviews so far
67%
saidit'sworth it
72%
saiditworked well
22%
saidit'sa big hassle

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
The Lidoderm (Lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Changes to the heartbeat
    • History of heart disease
  • Higher risk for seizures
    • History of seizures
    • History of brain damage or alcohol withdrawal
See more detailed risks and warnings
  • Overdose
    • Use of heating pad on skin
    • Applying patch to red, irritated or broken skin
    • Leaving patch on for more than 12 hours
    • Using patch on a very large area
    • Older age and lower body weight
    • Liver disease
  • Serious allergic reaction
    • Allergy to numbing medications (local anesthetics)
  • Accidental poisoning
    • Not disposing of Lidoderm (Lidocaine) correctly
    • Children and pets can reach medication
  • Eye irritation
    • Not washing hands after touching or applying Lidoderm (Lidocaine)
  • Skin reactions
    • Applying Lidoderm (Lidocaine) to warm skin
    • Covering patch with wrap or heating pad
  • Heart problems
    • History of heart problems
    • Using Lidoderm (Lidocaine) with drugs to treat irregular heartbeat
See more detailed risks and warnings