Compare desipramine vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin
(desipramine)

Oleptro
(trazodone)

Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Reviews & ratings
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Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-73% worse vs. desipramine
49%
-49% worse vs. desipramine
24%
+24% better vs. desipramine
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
desipramineOleptro

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
  • Somnolence/Sedation 27%
  • Drowsiness 21%
  • Dry Mouth 14%
  • Headache 6%
  • Dizziness/Lightheadedness 13%
  • Dry mouth 12%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
desipramineOleptro
Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
desipramineOleptro
Prescription onlyPrescription only
Available as
desipramineOleptro
  • Pill
  • Pill
  • Extended release
Used for
desipramineOleptro
Risk factors for serious side effects
desipramineOleptro
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
desipramineOleptro
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
desipramineOleptro
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
desipramineOleptro
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it