Compare desipramine vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin
(desipramine)

Zoloft
(sertraline)

Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Coupons for Zoloft
Best available price for 30 (100mg) tablets of zoloft
Reviews & ratings
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Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Reviews for Zoloft
59%
-59% worse vs. desipramine
41%
-41% worse vs. desipramine
15%
+15% better vs. desipramine
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
desipramineZoloft

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
  • Nausea 14%
  • Diarrhea/loose stools 9%
  • Sleep difficulty 7%
  • Mouth dry 7%
  • Drowsiness 7%
  • Dizziness 5%
  • Tremor 8%
  • Fatigue 3%
  • Sweating increased 5%
  • Constipation 2%
More Zoloft side effects »
How it works
desipramineZoloft
Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
desipramineZoloft
Prescription onlyPrescription only
Available as
desipramineZoloft
  • Pill
  • Pill
  • Liquid
Used for
desipramineZoloft
Risk factors for serious side effects
desipramineZoloft
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
  • Under 24 years old
  • Interactions with other medications
  • Stopping Zoloft (Sertraline) suddenly
  • Taking with blood-thinning drugs
  • Elderly
Detailed Zoloft (sertraline) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
desipramineZoloft
No interactions related info.
  • It interacts with St. John's Wort and Tryptophan.
Sex
desipramineZoloft
No sex related info.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
Sleep
desipramineZoloft
No sleep related info.
  • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
  • Causes less drowsiness than other antidepressants.
Upsides and benefits
desipramineZoloft
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
  • Causes less drowsiness than other antidepressants.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
desipramineZoloft
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • More likely to cause diarrhea than other antidepressants.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
desipramineZoloft
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • It interacts with St. John's Wort and Tryptophan.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
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More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it