Compare dexamethasone vs. fludrocortisone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Decadron (dexamethasone)

Prescription only

Fludrocortisone

Prescription only
Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Treats electrolyte imbalance.

Fludrocortisone is one of the first choices used in Addison's disease to help maintain your electrolytes, but there are side effects.

Upsides
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Fludrocortisone is effective in correcting electrolyte imbalances associated with Addison's disease.
  • Generic is available.
  • Only need to take it once daily.
Downsides
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Fludrocortisone can cause reactivation of old infections such as Hepatits B, C, or tuberculosis.
  • Fludrocortisone can make it easier for you to get sick.
  • Fludrocortisone can interact with other drugs and vaccines.
  • While on Fludrocortisone, you may need to have blood tests done for monitoring.
Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
  • Addison's disease
  • Congential adrenal hyperplasia
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$9.85
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Lowest price near you
$13.96
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Reviews
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Side effects
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
The Fludrocortisone FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Recent heart attack

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

  • Bone effects

    Dose of Decadron (dexamethasone)

    ...and 1 more risk factors

See more detailed risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Bone effects

    Dose of Fludrocortisone

    ...and 1 more risk factors

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

See more detailed risks and warnings