Compare dexamethasone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Decadron (dexamethasone)

Prescription only
Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Calms down your immune system.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

5.1/ 7 average rating with 66 reviewsforMedrol
Upsides
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
Downsides
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Injection
Price
Lowest price near you
$9.85
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Lowest price near you
$16.67
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Reviews
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66 
59%
think this treatment is worth it
53%
think this treatment works well
23%
think this treatment is a hassle

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Side effects
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
The Medrol (methylprednisolone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Recent heart attack

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

  • Bone effects

    Dose of Decadron (dexamethasone)

    ...and 1 more risk factors

See more detailed risks and warnings
  • Weakened immune system response to stress

    Taking high doses of Medrol (methylprednisolone) for a long period of time

    ...and 2 more risk factors

  • Increased risk for infections

    Taking other medicines that weaken the immune system

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Those who had a recent heart attack

    ...and 1 more risk factors

  • Eye problems

    Those with cataracts and/or glaucoma

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Pregnant women

    ...and 1 more risk factors

See more detailed risks and warnings