Compare dexamethasone vs. Provigil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Decadron (dexamethasone)

Prescription only

Provigil (Modafinil)

Prescription only
Calms down your immune system.

Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.

Improves alertness.

Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.

5.8/ 7 average rating with 28 reviewsforProvigil
Upsides
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
Downsides
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.
Used for
  • Allergies
  • Skin Conditions
  • Endocrine Conditions
  • Eye Conditions
  • Stomach Conditions
  • Respiratory disorder
  • Multiple sclerosis flare
  • Hematologic Conditions
  • Cancer
  • Autoimmune and Rheumatic Conditions
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$9.85
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Lowest price near you
$35
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Reviews
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28 
82%
think this treatment is worth it
71%
think this treatment works well
4%
think this treatment is a hassle

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Side effects
The Decadron (dexamethasone) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Headache
    34%
  • Nausea
    11%
  • Any side effect
    8%
  • Nervousness
    7%
  • Rhinitis
    7%
  • Back Pain
    6%
  • Diarrhea
    6%
  • Dyspepsia
    5%
  • Insomnia
    5%
  • Anxiety
    5%
See more detailed side effects
Risks and warnings
  • Lowered adrenal function

    Lowering dose or stopping too quickly especially after long-term treatment

    ...and 1 more risk factors

  • Increased risk for infections

    Taking other immunosuppressants

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Recent heart attack

  • Stomach and intestinal problems

    History of stomach bleeding

    ...and 3 more risk factors

  • Bone effects

    Dose of Decadron (dexamethasone)

    ...and 1 more risk factors

See more detailed risks and warnings
  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

  • Increased side effects

    Current kidney problems

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Suicidal thoughts or behavior | Mania

    History of psychiatric disorder

    ...and 1 more risk factors

See more detailed risks and warnings