Compare Dexedrine vs. Adderall

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexedrine
(dextroamphetamine)

Adderall
(dextroamphetamine / amphetamine)

Helps you stay awake and focus. Dexedrine (Dextroamphetamine) is an effective and cheap medication used to treat ADHD, but it can be habit-forming and is not used for long-term treatment.Helps you focus and stay alert. Adderall (Dextroamphetamine / Amphetamine) is a first-choice treatment for ADHD that's available as a generic, but it's a stimulant, so it can cause insomnia and other side effects.
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Coupons for Dexedrine
Best available price for 60 (5mg) tablets of dextroamphetamine
Coupons for Adderall
Best available price for 60 (20mg) tablets of adderall
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.89Dexedrine
Reviews for Dexedrine
89%
of people (All ages) say Dexedrine is worth it
79%
say it works well
21%
say it's a big hassle
Have you used Dexedrine (dextroamphetamine)?
Worth itNot sureNot worth it
Reviews for Adderall
74%
+15% better vs. Dexedrine
53%
+26% better vs. Dexedrine
16%
-5% worse vs. Dexedrine
1309 reviews
Have you used Adderall (dextroamphetamine / amphetamine)?
Worth itNot sureNot worth it
Side effects
DexedrineAdderall

We haven’t found good data for Dexedrine side effects.

FDA side effect reports for Dexedrine »

The Adderall FDA package insert doesn’t have numbers about how common side effects are.

More about Adderall side effects »
How it works
DexedrineAdderall
Dexedrine (Dextroamphetamine) is a stimulant. It treats narcolepsy and attention-deficit/hyperactivity disorder (ADHD) by increasing norepinephrine and dopamine activity in the brain.Adderall (Dextroamphetamine / Amphetamine) is an amphetamine stimulant. Researchers don't know exactly how it works for ADHD, but it increases norepinephrine and dopamine activity in the brain, which affects attention and behavior.
Type of medication
DexedrineAdderall
Prescription onlyPrescription only
Available as
DexedrineAdderall
  • Pill
  • Extended release
  • Liquid
  • Pill
  • Extended release
Used for
DexedrineAdderall
Risk factors for serious side effects
DexedrineAdderall
  • History of heart problems
  • History of drug abuse
  • History of psychotic episodes
  • History of bipolar disorder
  • Children
Detailed Dexedrine (dextroamphetamine) risks & warnings »
  • History of heart problems
  • History of drug abuse
  • Taking more than the prescribed dose
  • History of high blood pressure
  • History of psychotic episodes
Detailed Adderall (dextroamphetamine / amphetamine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
DexedrineAdderall
No alcohol related info.
  • Don't take it with alcohol or drugs.
Weight
DexedrineAdderall
No weight related info.
  • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
Upsides and benefits
DexedrineAdderall
  • Recommended as a first-choice medication to treat ADHD in both adults and children.
  • Available as a generic, so it is cheaper than other medications used to treat ADHD.
  • Available in an immediate release and extended release form, which allows for once or twice a day dosing.
  • First-choice medication to treat ADHD.
  • Adderall (Dextroamphetamine / Amphetamine) is used in combination with counseling or other non-drug therapies to treat ADHD.
  • Available as a generic medication.
  • Available in both immediate and extended release forms.
  • The capsules can be opened, mixed in a spoonful of applesauce, and swallowed if you can't swallow the whole capsules.
Downsides and risks
DexedrineAdderall
  • Fruit juice lowers the amount of Dexedrine (Dextroamphetamine) that gets into your body.
  • If you want to stop taking Dexedrine (Dextroamphetamine), you have to talk to your doctor since stopping cold turkey can cause withdrawal symptoms.
  • Dexedrine (Dextroamphetamine) is usually not used long-term since it can be habit-forming.
  • Has to be taken in the morning and early afternoon, otherwise it can cause insomnia.
  • It's a controlled medication and should be locked up to prevent potential abuse.
  • Not safe for people with a history of heart problems.
  • For schooled-aged children, the second dose will likely need to be given at school.
Tips from our pharmacists for people taking the medication
DexedrineAdderall
  • Take your last dose before early afternoon, otherwise you won't be able to sleep.
  • Don't take with fruit juice or vitamin C, because they'll lower the amount of Dexedrine (Dextroamphetamine) that gets into your body.
  • Can affect your concentration, so don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you've been taking Dexedrine (Dextroamphetamine) for a while and decide to stop it, you'll experience withdrawal symptoms if you stop it too fast.
  • Can cause reduced appetite, insomnia, and restlessness.
  • Can cause blurry vision, loss of appetite, weight loss, headache, dry mouth, or anxious feelings.
  • Don't take it with alcohol or drugs.
  • Can cause trouble sleeping, so don't take it too close to bedtime.
  • If using the extended-release version, the first dose is best taken right after waking up in the morning.
  • Capsules can be opened and sprinkled on applesauce, which can then be swallowed without chewing.
Learn more
More about DexedrineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dexedrine (dextroamphetamine)?
Worth itNot sureNot worth it
More about AdderallSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Adderall (dextroamphetamine / amphetamine)?
Worth itNot sureNot worth it