Compare Dexilant vs. Nexium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nexium (esomeprazole)

Over-the-counter
Treats heartburn and ulcers.

Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

4.7/ 5 average rating with 73 reviewsforDexilant
Treats heartburn and stomach ulcers.

Nexium (esomeprazole) gives you long-lasting heartburn relief but has some risks if used long term.

4.0/ 5 average rating with 1239 reviewsforNexium
Upsides
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Nexium (esomeprazole) without any noticeable day-to-day side effects.
  • Nexium (esomeprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need quicker relief.
  • Nexium (esomeprazole) is inexpensive, with over-the-counter and generic options.
  • Coupons are available for the brand name - speak to your doctor or pharmacist.
  • The packet form is a good option if you have trouble swallowing pills.They can be mixed with water for easier swallowing.
Downsides
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Doesn't start working right away like antacids (Tums, Rolaids, or Maalox).
  • It can take several days or weeks to start feeling benefits.
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and severe diarrhea.
Used for
  • GERD
  • H. Pylori bacterial infection
  • Prevention and treatment of NSAID-induced gastric ulcers
Dosage forms
  • Extended release
  • Pill
  • Injection
  • Packet
Price
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Reviews
73 reviews so far
93%
saidit'sworth it
92%
saiditworked well
14%
saidit'sa big hassle

Have you used Dexilant (Dexlansoprazole)?

Leave a review
1239 reviews so far
75%
saidit'sworth it
59%
saiditworked well
11%
saidit'sa big hassle

Have you used Nexium (esomeprazole)?

Leave a review
Side effects
6possible side effects
  • Diarrhea
    5%
  • Abdominal Pain
    4%
  • Nausea
    3%
  • Upper Respiratory Tract Infection
    2%
  • Vomiting
    2%
  • Flatulence
    2%
See more detailed side effects
The Nexium (esomeprazole) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Hiding possible cancer
  • Severe stomach inflammation (atrophic gastritis)
    • Helicobacter pylori infection
    • Autoimmune disease
  • Severe diarrhea
    • Being hospitalized
    • Antibiotic use
  • Broken bones
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
  • Low vitamin or mineral levels
See more detailed risks and warnings
  • Stomach cancer
  • Kidney injury
  • Severe diarrhea
    • Being treated at a hospital
  • Bone fractures
    • High dose Nexium (esomeprazole)
    • Long-term treatment with Nexium (esomeprazole)
    • Low bone mineral density
    • Aged 65 years or older
  • Lupus
See more detailed risks and warnings