Compare Dexilant vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant (Dexlansoprazole)

Prescription only

Prilosec (Omeprazole)

Prescription or OTC
Treats heartburn and ulcers.

Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

6.6/ 7 average rating with 73 reviewsforDexilant
Treats heartburn and stomach ulcers.

Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

5.5/ 7 average rating with 1167 reviewsforOmeprazole
Upsides
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
Used for
Dosage forms
  • Extended release
  • Extended release
Price
Lowest price near you
$273.02
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Lowest price near you
$4
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Reviews
73 
93%
think this treatment is worth it
92%
think this treatment works well
14%
think this treatment is a hassle

Have you used Dexilant (Dexlansoprazole)?

Leave a review
1167 
80%
think this treatment is worth it
59%
think this treatment works well
8%
think this treatment is a hassle

Have you used Prilosec (Omeprazole)?

Leave a review
Side effects
6possible side effects
  • Diarrhea
    5%
  • Abdominal Pain
    4%
  • Nausea
    3%
  • Upper Respiratory Tract Infection
    2%
  • Vomiting
    2%
  • Flatulence
    2%
See more detailed side effects
9possible side effects
  • Upper respiratory infection
    75%
  • Fever
    33%
  • Headache
    7%
  • Abdominal pain
    5%
  • Nausea
    4%
  • Diarrhea
    4%
  • Accidental injuries
    4%
  • Vomiting
    3%
  • Flatulence
    3%
See more detailed side effects
Risks and warnings
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones

    Osteoporosis

    ...and 5 more risk factors

See more detailed risks and warnings
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones

    Osteoporosis

    ...and 5 more risk factors

See more detailed risks and warnings