Compare Dexilant vs. pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant
(dexlansoprazole)

Protonix
(pantoprazole)

Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.
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Coupons for Dexilant
Best available price for 30 (60mg) capsules of dexilant
Coupons for pantoprazole
Best available price for 30 (40mg) tablets of pantoprazole
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
6.6Dexilant
Reviews for Dexilant
93%
of people (All ages) say Dexilant is worth it
92%
say it works well
14%
say it's a big hassle
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
Reviews for pantoprazole
68%
+25% better vs. Dexilant
51%
+41% better vs. Dexilant
13%
-1% worse vs. Dexilant
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Side effects
Dexilantpantoprazole
  • Diarrhea 2%
  • Ear, nose, or throat infection 1%
  • Vomiting 1%
  • Passing gas 1%
More Dexilant side effects »
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
How it works
Dexilantpantoprazole
Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.
Type of medication
Dexilantpantoprazole
Prescription onlyPrescription only
Available as
Dexilantpantoprazole
  • Extended release
  • Pill
  • Packet
Used for
Dexilantpantoprazole
Risk factors for serious side effects
Dexilantpantoprazole
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Dexilant (dexlansoprazole) risks & warnings »
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
Dexilantpantoprazole
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
No interactions related info.
Food
Dexilantpantoprazole
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
Kidneys and liver
Dexilantpantoprazole
No kidneys and liver related info.
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
Pain
Dexilantpantoprazole
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
Upsides and benefits
Dexilantpantoprazole
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
Downsides and risks
Dexilantpantoprazole
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
Tips from our pharmacists for people taking the medication
Dexilantpantoprazole
  • Can take a few days to start working.
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
Learn more
More about DexilantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it