Compare Dexilant vs. pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant (Dexlansoprazole)

Prescription only

Protonix (pantoprazole)

Prescription only
Treats heartburn and ulcers.

Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.

6.6/ 7 average rating with 73 reviewsforDexilant
Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

5.1/ 7 average rating with 584 reviewsforpantoprazole
Upsides
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
Downsides
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
Used for
Dosage forms
  • Extended release
  • Pill
  • Packet
Price
Lowest price near you
$273.02
Find instant savings
Lowest price near you
$9.35
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
73 
93%
think this treatment is worth it
92%
think this treatment works well
14%
think this treatment is a hassle

Have you used Dexilant (Dexlansoprazole)?

Leave a review
584 
68%
think this treatment is worth it
51%
think this treatment works well
13%
think this treatment is a hassle

Have you used Protonix (pantoprazole)?

Leave a review
Side effects
6possible side effects
  • Diarrhea
    5%
  • Abdominal Pain
    4%
  • Nausea
    3%
  • Upper Respiratory Tract Infection
    2%
  • Vomiting
    2%
  • Flatulence
    2%
See more detailed side effects
8possible side effects
  • Headache
    12%
  • Diarrhea
    9%
  • Nausea
    7%
  • Stomach pain
    6%
  • Vomiting
    4%
  • Gas
    4%
  • Dizziness
    3%
  • Joint pain
    3%
See more detailed side effects
Risks and warnings
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones

    Osteoporosis

    ...and 5 more risk factors

See more detailed risks and warnings
  • Weakened bones

    Using multiple daily doses and/or for 1 year or longer

    ...and 2 more risk factors

  • Severe diarrhea

    People who are being treated in the hospital

  • Lupus

    People with lupus

  • Low Vitamin B-12 level

    Taking Protonix (pantoprazole) for more than 3 years

  • Low magnesium level

    Diuretics (water pills)

    ...and 1 more risk factors

See more detailed risks and warnings