Compare Dexilant vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant
(dexlansoprazole)

Pepcid
(famotidine)

Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Dexilant
Best available price for 30 (60mg) capsules of dexilant
Coupons for Pepcid
Best available price for 60 (20mg) tablets of famotidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
6.6Dexilant
Reviews for Dexilant
93%
of people (All ages) say Dexilant is worth it
92%
say it works well
14%
say it's a big hassle
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
Reviews for Pepcid
75%
+18% better vs. Dexilant
41%
+51% better vs. Dexilant
8%
-6% worse vs. Dexilant
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Side effects
DexilantPepcid
  • Diarrhea 2%
  • Ear, nose, or throat infection 1%
  • Vomiting 1%
  • Passing gas 1%
More Dexilant side effects »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
How it works
DexilantPepcid
Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
DexilantPepcid
Prescription onlyPrescription or OTC
Available as
DexilantPepcid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for
DexilantPepcid
Risk factors for serious side effects
DexilantPepcid
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Dexilant (dexlansoprazole) risks & warnings »
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
DexilantPepcid
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • Few drug interactions.
Food
DexilantPepcid
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
No food related info.
Kidneys and liver
DexilantPepcid
No kidneys and liver related info.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Pain
DexilantPepcid
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
No pain related info.
Upsides and benefits
DexilantPepcid
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
Downsides and risks
DexilantPepcid
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
Tips from our pharmacists for people taking the medication
DexilantPepcid
  • Can take a few days to start working.
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
  • Short-term treatment of ulcers and acid reflux.
Learn more
More about DexilantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it