Compare Dexilant vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant
(Dexlansoprazole)

Pepcid
(Famotidine)

Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
6.72093023255814Dexilant
Reviews for Dexilant (Dexlansoprazole)
93%
of people say Dexilant (Dexlansoprazole) is worth it
93%
say it works well
9%
say it's a big hassle
Reviews for Pepcid (Famotidine)
75%
18% vs. Dexilant (Dexlansoprazole)
41%
52% vs. Dexilant (Dexlansoprazole)
8%
+1% vs. Dexilant (Dexlansoprazole)
Side effects
DexilantPepcid
  • Diarrhea 2%
  • Ear, nose, or throat infection 2%
  • Passing gas 2%
  • Vomiting 1%
More Dexilant side effects »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
How it works
DexilantPepcid
Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
DexilantPepcid
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Available as
DexilantPepcid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
DexilantPepcid
Risk factors for serious side effects
DexilantPepcid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Dexilant (Dexlansoprazole) risks & warnings »
        • Current kidney disease
          Detailed Pepcid (Famotidine) risks & warnings »
          Pregnancy category
          DexilantPepcid
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          DexilantPepcid
          • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
          • Lasts longer than other similar stomach medicines. Most people take it once a day.
          • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
          • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
          • Most people can take Famotidine without any noticeable day-to-day side effects.
          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Few drug interactions.
          Downsides and risks
          DexilantPepcid
          • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
          • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
          • There's no generic version available, so it can be expensive.
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          Tips from our pharmacists for people taking the medication
          DexilantPepcid
          • Can take a few days to start working.
          • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
          • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
          • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
          • Short-term treatment of ulcers and acid reflux.
          Learn more
          More about DexilantSide effectsReviews & ratingsAlternativesFDA package insert
          More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert