Compare Dexilant vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant
(dexlansoprazole)

Tagamet
(cimetidine)

Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
6.6Dexilant
Reviews for Dexilant
93%
of people (All ages) say Dexilant is worth it
92%
say it works well
14%
say it's a big hassle
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet
63%
+30% better vs. Dexilant
36%
+56% better vs. Dexilant
12%
-2% worse vs. Dexilant
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
DexilantTagamet
  • Diarrhea 2%
  • Ear, nose, or throat infection 1%
  • Vomiting 1%
  • Passing gas 1%
More Dexilant side effects »
  • Headache 2%
More Tagamet side effects »
How it works
DexilantTagamet
Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (cimetidine) reduces acid production in your stomach.
Type of medication
DexilantTagamet
Prescription onlyPrescription or OTC
Available as
DexilantTagamet
  • Extended release
  • Pill
  • Liquid
Used for
DexilantTagamet
Risk factors for serious side effects
DexilantTagamet
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Dexilant (dexlansoprazole) risks & warnings »
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
DexilantTagamet
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
No interactions related info.
Food
DexilantTagamet
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
No food related info.
Kidneys and liver
DexilantTagamet
No kidneys and liver related info.
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
Pain
DexilantTagamet
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
No pain related info.
Upsides and benefits
DexilantTagamet
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides and risks
DexilantTagamet
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Tips from our pharmacists for people taking the medication
DexilantTagamet
  • Can take a few days to start working.
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
Learn more
More about DexilantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it