Compare Dexilant vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dexilant
(dexlansoprazole)

Tagamet
(cimetidine)

Treats heartburn and ulcers. Dexilant (Dexlansoprazole) is an effective medicine to treat heartburn and ulcers, but can be expensive.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Dexilant
Best available price for 30 (60mg) capsules of dexlansoprazole
Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
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Filter group. All currently selected
6.6Dexilant
Reviews for Dexilant (dexlansoprazole)
93%
of people (All ages) say Dexilant (dexlansoprazole) is worth it
92%
say it works well
14%
say it's a big hassle
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet (cimetidine)
63%
-30% worse vs. Dexilant (dexlansoprazole)
36%
-56% worse vs. Dexilant (dexlansoprazole)
12%
+2% better vs. Dexilant (dexlansoprazole)
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
DexilantTagamet
  • Diarrhea 2%
  • Ear, nose, or throat infection 1%
  • Vomiting 1%
  • Passing gas 1%
More Dexilant side effects »
  • Abnormally large breasts in males 4%
  • Headache 2%
More Tagamet side effects »
How it works
DexilantTagamet
Dexilant (Dexlansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
DexilantTagamet
Prescription only
Prescription or OTC
Available as
DexilantTagamet
  • Extended release
  • Pill
  • Liquid
Used for
DexilantTagamet
Risk factors for serious side effects
DexilantTagamet
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Dexilant (dexlansoprazole) risks & warnings »
  • Current kidney disease
  • Current liver disease
  • Age 50 or older
  • Current severe illness
  • Autoimmune disease
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
DexilantTagamet
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • Has more drug interactions than zantac and pepcid.
Food
DexilantTagamet
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
No food related info.
Kidneys and liver
DexilantTagamet
No kidneys and liver related info.
  • People with kidney disease may need to take a lower dose.
Pain
DexilantTagamet
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
No pain related info.
Upsides and benefits
DexilantTagamet
  • Relieves heartburn symptoms and heals ulcers better than other stomach medicines, such as Pepcid, Tagamet, and Zantac.
  • Lasts longer than other similar stomach medicines. Most people take it once a day.
  • Your body won't develop a tolerance to Dexilant (Dexlansoprazole), so it'll work the same way as long as you need to keep taking it.
  • Once heartburn symptoms are treated, a low dose of Dexilant (Dexlansoprazole) can be taken daily.
  • Most people can take Cimetidine without any noticeable day-to-day side effects.
  • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides and risks
DexilantTagamet
  • Taking Dexilant (Dexlansoprazole) in high doses or for longer than 1 year can increase the risk for bone fractures, especially if you already have osteoporosis (weak bones).
  • Many drugs can interact with Dexilant (Dexlansoprazole), so talk to your doctor or pharmacist before starting any new medicines.
  • There's no generic version available, so it can be expensive.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
  • Has more drug interactions than zantac and pepcid.
  • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
Tips from our pharmacists for people taking the medication
DexilantTagamet
  • Can take a few days to start working.
  • Take Dexilant (Dexlansoprazole) with or without food. It can work better for some people if it's taken 30 minutes before a meal.
  • Call your doctor if you have watery stools, stomach pain, or a fever because it could be a sign of a serious infection.
  • Dexilant (Dexlansoprazole) can lower the amount of magnesium in your body. Initial and follow-up blood tests may be needed before starting Dexilant (Dexlansoprazole).
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
Learn more
More about DexilantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dexilant (dexlansoprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it