Compare Diclofenac vs. Celebrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex (Diclofenac)

Prescription only

Celebrex (Celecoxib)

Prescription only
Treats arthritis pain and swelling.

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

Relieves pain and inflammation.

Celebrex (Celecoxib) works well for treating pain and causes less upset stomach than other NSAIDs.

4.6/ 7 average rating with 550 reviewsforCelebrex
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Relieves pain and inflammation for many types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for treating muscle aches and pains, as well as menstrual cramps.
  • Causes fewer stomach problems than other NSAIDs like Ibuprofen or Naproxen.
  • Lasts longer than Ibuprofen.
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • The longer you take Celebrex (Celecoxib), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. Can also happen if you take Celebrex (Celecoxib) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
Used for
Dosage forms
  • Pill
  • Pill
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Side effects
9possible side effects
  • Upper respiratory tract infection
  • Headache
  • Nausea
  • Urinary tract infection
  • Diarrhea
  • Nasopharyngitis
  • Constipation
  • Sinusitis
  • Osteoarthritis
See more detailed side effects
The Celebrex (Celecoxib) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart attack or stroke

    History of heart problems

    ...and 5 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 1 more risk factors

  • Bruising or bleeding

    Bleeding disorder

    ...and 1 more risk factors

  • Serious allergic reactions


    ...and 4 more risk factors

  • Lowers kidney function

    Kidney problems

    ...and 5 more risk factors

  • Increased blood pressure

    History of high blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings
  • Heart attack and stroke

    Long-term use

    ...and 2 more risk factors

  • Stomach bleeding

    Age 65 or older

    ...and 1 more risk factors

  • Increased blood pressure

    History of high blood pressure

    ...and 1 more risk factors

  • Increased swelling (edema) and fluid retention

    History of heart failure

  • Asthma attacks

    History of asthma

  • Lowered kidney function

    Kidney Disease

    ...and 6 more risk factors

  • Harm to unborn babies

    Late pregnancy (more than 30 weeks)

See more detailed risks and warnings