Compare Diclofenac vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(Diclofenac)

Coumadin
(Warfarin)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.
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Reviews & ratings
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Reviews for Coumadin (Warfarin)
61%
39% vs. Zorvolex (Diclofenac)
54%
46% vs. Zorvolex (Diclofenac)
21%
21% vs. Zorvolex (Diclofenac)
Side effects
DiclofenacCoumadin
  • Constipation 4%
  • Diarrhea 3%
  • Abdominal pain upper 2%
  • Pain in extremity 2%
  • Itching 1%
  • Swelling due to excess fluid 1%
  • Passing gas 1%
More Diclofenac side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
DiclofenacCoumadin
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.
Type of medication
DiclofenacCoumadin
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Anticoagulant
Vitamin K antagonist
Prescription only
Available as
DiclofenacCoumadin
  • Pill
  • Pill
Used for (click to learn more)
DiclofenacCoumadin
  • Osteoarthritis pain
Risk factors for serious side effects
DiclofenacCoumadin
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (Diclofenac) risks & warnings »
  • Dose too high
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Illnesses
  • Alcohol
  • Certain genetic makeup
    • Women of childbearing age
    Detailed Coumadin (Warfarin) risks & warnings »
    Pregnancy category
    DiclofenacCoumadin
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    Alcohol
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    Food
    • Take it with food to avoid getting diarrhea.
    • Eat foods containing consistent amounts of Vitamin K.
    Kidneys and liver
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    DiclofenacCoumadin
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Available as a generic.
    • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
    • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
    • Has an antidote, Vitamin K, in case of a major accidental bleeding.
    • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
    • It's dirt cheap.
    Downsides and risks
    DiclofenacCoumadin
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • Raises your risk of bleeding and bruising.
    • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    Tips from our pharmacists for people taking the medication
    DiclofenacCoumadin
    • Take it with food to avoid getting diarrhea.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
    • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • The amount you need depends on your diet, other medical problems, and genes.
    • Take it exactly as instructed.
    • Can raise your risk of bleeding or bruising.
    • Requires regular blood tests to get your dose right.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Eat foods containing consistent amounts of Vitamin K.
    • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
    • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
    Learn more
    More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
    More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert