Compare Diclofenac vs. Coumadin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(diclofenac)

Coumadin
(warfarin)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.
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Reviews & ratings
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Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it
Reviews for Coumadin (warfarin)
61%
-39% worse vs. Zorvolex (diclofenac)
54%
-46% worse vs. Zorvolex (diclofenac)
21%
-21% worse vs. Zorvolex (diclofenac)
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Side effects
DiclofenacCoumadin
  • Swelling due to excess fluid 1%
  • Constipation 4%
  • Itching 1%
  • Passing gas 1%
  • Pain in extremity 2%
  • Indigestion 1%
More Diclofenac side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
How it works
DiclofenacCoumadin
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.
Type of medication
DiclofenacCoumadin
Prescription only
Prescription only
Available as
DiclofenacCoumadin
  • Pill
  • Pill
Used for
DiclofenacCoumadin
  • Osteoarthritis Pain
Risk factors for serious side effects
DiclofenacCoumadin
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (diclofenac) risks & warnings »
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
  • Drug interactions
  • Change in lifestyle or diet
  • Alcohol use
  • Certain genetic factors
  • Women of childbearing age
      Detailed Coumadin (warfarin) risks & warnings »
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      Interactions
      DiclofenacCoumadin
      No interactions related info.
      • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
      • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
      Alcohol
      DiclofenacCoumadin
      • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
      • Don't drink alcohol while using Zorvolex (Diclofenac).
      No alcohol related info.
      Food
      DiclofenacCoumadin
      • Take it with food to avoid getting diarrhea.
      No food related info.
      Kidneys and liver
      DiclofenacCoumadin
      • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
      No kidneys and liver related info.
      Pain
      DiclofenacCoumadin
      • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
      • Can be used as needed to treat pain and swelling.
      • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
      No pain related info.
      Upsides and benefits
      DiclofenacCoumadin
      • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
      • Can be used as needed to treat pain and swelling.
      • Available as a generic.
      • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
      • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
      • Coumadin (warfarin) comes in numerous strengths.
      • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
      Downsides and risks
      DiclofenacCoumadin
      • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
      • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
      • Raises your risk of bleeding and bruising.
      • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
      • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
      • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
      Tips from our pharmacists for people taking the medication
      DiclofenacCoumadin
      • Take it with food to avoid getting diarrhea.
      • Don't drink alcohol while using Zorvolex (Diclofenac).
      • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
      • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
      • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
      • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
      • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
      • Take Coumadin (warfarin) exactly as your doctor tells you.
      • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
      • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
      • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
      • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
      Learn more
      More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Zorvolex (diclofenac)?
      Worth itNot sureNot worth it
      More about CoumadinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Coumadin (warfarin)?
      Worth itNot sureNot worth it