Compare Diclofenac vs. Lodine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(diclofenac)

Lodine
(etodolac)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Coming soon.
Reviews & ratings
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Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it

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Have you used Lodine (etodolac)?
Worth itNot sureNot worth it
Side effects
DiclofenacLodine
  • Edema 1%
  • Constipation 4%
  • Pruritus 1%
  • Flatulence 1%
  • Pain in extremity 2%
  • Dyspepsia 1%
More Diclofenac side effects »

We haven’t found good data for Lodine side effects.

FDA side effect reports for Lodine »
How it works
DiclofenacLodine
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Coming soon.
Type of medication
DiclofenacLodine
Prescription only
Available as
DiclofenacLodine
  • Pill
  • Pill
  • Extended release
Used for
DiclofenacLodine
  • Osteoarthritis Pain
  • Juvenile Rheumatoid Arthritis Osteoarthritis Pain Rheumatoid Arthritis
Risk factors for serious side effects
DiclofenacLodine
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Zorvolex (diclofenac) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    DiclofenacLodine
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    No alcohol related info.
    Food
    DiclofenacLodine
    • Take it with food to avoid getting diarrhea.
    No food related info.
    Kidneys and liver
    DiclofenacLodine
    • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
    No kidneys and liver related info.
    Pain
    DiclofenacLodine
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    No pain related info.
    Upsides and benefits
    DiclofenacLodine
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Available as a generic.
    Coming soon
    Downsides and risks
    DiclofenacLodine
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    Coming soon
    Tips from our pharmacists for people taking the medication
    DiclofenacLodine
    • Take it with food to avoid getting diarrhea.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
    • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
    Coming soon
    Learn more
    More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zorvolex (diclofenac)?
    Worth itNot sureNot worth it
    More about LodineSide effectsReviews & ratingsFDA package insert
    Have you used Lodine (etodolac)?
    Worth itNot sureNot worth it