Compare Diclofenac vs. Lodine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats arthritis pain and swelling.

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

No information currently available
Upsides
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
No information currently available
Downsides
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
No information currently available
Used for
  • Osteoarthritis pain
  • Juvenile rheumatoid arthritis Osteoarthritis Pain Rheumatoid arthritis
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
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Side effects
28possible side effects
  • Upper respiratory tract infection
    8%
  • Headache
    8%
  • Nausea
    7%
  • Urinary tract infection
    7%
  • Diarrhea
    6%
  • Nasopharyngitis
    6%
  • Constipation
    5%
  • Sinusitis
    5%
  • Osteoarthritis
    5%
  • Cough
    4%
  • Alanine aminotransferase increased
    4%
  • Abdominal pain upper
    3%
  • Vomiting
    3%
  • Back pain
    3%
  • Dyspepsia
    3%
  • Procedural pain
    3%
  • Bronchitis
    3%
  • Hypertension
    3%
  • Influenza
    3%
  • Arthralgia
    3%
  • Contusion
    3%
  • Blood creatinine increased
    2%
  • Flatulence
    2%
  • Abdominal discomfort
    2%
  • Aspartate aminotransferase increased
    2%
  • Dizziness
    2%
  • Fall
    2%
  • Abdominal pain
    2%
See more detailed side effects
The Lodine (Etodolac) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack or stroke
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
  • Stomach bleeding
    • History of stomach bleeding or ulcers
    • Age 65 years or older
  • Bruising or bleeding
    • Bleeding disorder
    • Taking other blood-thinning medications
  • Serious allergic reactions
    • Asthma
    • Rhinitis
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Lowers kidney function
    • Kidney problems
    • Heart failure
    • Liver disease
    • Taking diuretics
    • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
    • Age 65 or older
  • Increased blood pressure
    • History of high blood pressure
    • Taking water pills (diuretics)
See more detailed risks and warnings
No information currently available
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.