Compare Diclofenac vs. Meloxicam

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(Diclofenac)

Mobic
(Meloxicam)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Relieves pain and inflammation. Mobic (Meloxicam) works well for treating pain and causes less upset stomach than other NSAIDs.
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Reviews & ratings
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Reviews for Mobic (Meloxicam)
56%
44% vs. Zorvolex (Diclofenac)
48%
52% vs. Zorvolex (Diclofenac)
16%
16% vs. Zorvolex (Diclofenac)
Side effects
DiclofenacMeloxicam
  • Constipation 4%
  • Diarrhea 3%
  • Abdominal pain upper 2%
  • Pain in extremity 2%
  • Itching 1%
  • Swelling due to excess fluid 1%
  • Passing gas 1%
More Diclofenac side effects »
  • Gastrointestinal disorders 5%
  • Diarrhea 4%
  • Infection and infestations 3%
  • Accident household 3%
  • Swelling due to excess fluid 2%
  • Dyspeptic signs and symptoms 2%
  • Sore throat 2%
  • Dizziness 1%
  • Flu-like symptomsa-like symptoms 1%
More Meloxicam side effects »
How it works
DiclofenacMeloxicam
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Mobic (Meloxicam) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.
Type of medication
DiclofenacMeloxicam
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Available as
DiclofenacMeloxicam
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
DiclofenacMeloxicam
  • Osteoarthritis pain
Risk factors for serious side effects
DiclofenacMeloxicam
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (Diclofenac) risks & warnings »
  • History of heart attack
  • History of heart surgery
  • High blood pressure
  • High Cholesterol
  • Diabetes
  • Being Overweight or Obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 or older
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Also taking anticoagulant medication
  • Asthma
  • Rhinitis
  • Nasal Polyps
  • Aspirin Allergy
  • NSAID Allergy
  • Kidney Disease
  • Heart Failure
  • Liver Disease
  • Also taking diuretics
  • Also taking ACE inhibitors
  • Also taking Angiotensin Receptor Blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
  • Late pregnancy (more than 30 weeks)
Detailed Mobic (Meloxicam) risks & warnings »
Pregnancy category
DiclofenacMeloxicam
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
No specific alcohol-related info.
Food
  • Take it with food to avoid getting diarrhea.
  • Take Mobic (Meloxicam) only once a day. Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Mobic (Meloxicam), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk for kidney problems. It is important to get lab tests to check your kidney function periodically if you use Mobic (Meloxicam) for long periods of time.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
DiclofenacMeloxicam
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Works well to relieve pain and inflammation from osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Good for muscle aches and pains.
  • It lasts longer than Ibuprofen, so you can take it less often.
  • Causes less upset stomach than other NSAIDs, like Ibuprofen.
  • Can also caus less bruising or bleeding than other NSAIDs when taken at lower doses (7.5 mg per day or less).
Downsides and risks
DiclofenacMeloxicam
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • The longer you take Mobic (Meloxicam), the more likely you are to have stomach problems, including inflammation, ulcers, and bleeding. This can also happen if you take Mobic (Meloxicam) on an empty stomach.
  • Like all NSAIDs, it can raise your risk of blood clots, heart attack, or a stroke.
  • Can also affect your kidneys or cause permanent kidney damage if taken for a long time.
Tips from our pharmacists for people taking the medication
DiclofenacMeloxicam
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
  • Take Mobic (Meloxicam) only once a day. Take it with a meal or a snack to prevent an upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
Learn more
More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
More about MeloxicamSide effectsReviews & ratingsAlternativesFDA package insert