Compare Diclofenac vs. meloxicam

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(diclofenac)

Mobic
(meloxicam)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Relieves pain and inflammation. Mobic (meloxicam) works well for pain and inflammation and you only take it once a day, but you need a prescription.
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Reviews & ratings
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Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it
Reviews for meloxicam
64%
+36% better vs. Diclofenac
54%
+46% better vs. Diclofenac
13%
+13% better vs. Diclofenac
141 reviews
Have you used Mobic (meloxicam)?
Worth itNot sureNot worth it
Side effects
Diclofenacmeloxicam
  • Swelling due to excess fluid 1%
  • Constipation 4%
  • Itching 1%
  • Passing gas 1%
  • Pain in extremity 2%
  • Indigestion 1%
More Diclofenac side effects »
  • Indigestion 10%
  • Ear, nose, or throat infection 8%
  • Nausea 7%
  • Urinary tract infection 7%
  • Pain 5%
  • Abdominal pain 3%
  • Constipation 3%
  • Diarrhea 3%
  • Gas 3%
  • Vomiting 3%
More meloxicam side effects »
How it works
Diclofenacmeloxicam
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Mobic (meloxicam) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves pain and swelling.
Type of medication
Diclofenacmeloxicam
Prescription onlyPrescription only
Available as
Diclofenacmeloxicam
  • Pill
  • Pill
  • Suspension
Used for
Diclofenacmeloxicam
  • Osteoarthritis Pain
Risk factors for serious side effects
Diclofenacmeloxicam
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Zorvolex (diclofenac) risks & warnings »
  • History of heart problems
  • Taking the medicine for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Mobic (meloxicam) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Diclofenacmeloxicam
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
No alcohol related info.
Food
Diclofenacmeloxicam
  • Take it with food to avoid getting diarrhea.
  • It should be taken only once a day, with food or milk to prevent stomach upset.
Kidneys and liver
Diclofenacmeloxicam
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
  • Mobic (meloxicam) can damage your kidneys if you take it for a very long time. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Mobic (meloxicam).
Pain
Diclofenacmeloxicam
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Mobic (meloxicam) can cause stomach bleeding which can be dangerous. If you notice blood in your vomit or your stool has bright red blood or looks like black coffee grounds, or if you have pain in your stomach that doesn't go away, talk to your doctor right away.
  • Works well to relieve pain and inflammation due to osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
Upsides and benefits
Diclofenacmeloxicam
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Taken only once a day, while other NSAIDS need to be taken a few times a day for the same effect.
  • Works well to relieve pain and inflammation due to osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis.
  • Causes less stomach upset than other NSAIDs.
  • Relatively cheap compared to other prescription NSAIDS.
Downsides and risks
Diclofenacmeloxicam
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Mobic (meloxicam) does not kick in as fast as other NSAIDS.
  • It's available by prescription only.
  • Mobic (meloxicam) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long time.
Tips from our pharmacists for people taking the medication
Diclofenacmeloxicam
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
  • It should be taken only once a day, with food or milk to prevent stomach upset.
  • Mobic (meloxicam) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • Do not take Mobic (meloxicam) with any blood thinners unless your doctor says so.
  • If you are allergic to aspirin, you may be allergic to Mobic (meloxicam) as well.
  • The capsule, suspension, and tablet forms of the medicine come in different strengths, so be careful when switching from one form to another.
Learn more
More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it
More about meloxicamSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Mobic (meloxicam)?
Worth itNot sureNot worth it