Compare Diclofenac vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex (Diclofenac)

Prescription only
Treats arthritis pain and swelling.

Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.

Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

4.8/ 7 average rating with 541 reviewsforMorphine Sulfate
Upsides
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Price
Lowest price near you
$334.28
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$201.89
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Reviews
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541 
55%
think this treatment is worth it
43%
think this treatment works well
20%
think this treatment is a hassle

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Side effects
9possible side effects
  • Upper respiratory tract infection
    8%
  • Headache
    8%
  • Nausea
    7%
  • Urinary tract infection
    7%
  • Diarrhea
    6%
  • Nasopharyngitis
    6%
  • Constipation
    5%
  • Sinusitis
    5%
  • Osteoarthritis
    5%
See more detailed side effects
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Heart attack or stroke

    History of heart problems

    ...and 5 more risk factors

  • Stomach bleeding

    History of stomach bleeding or ulcers

    ...and 1 more risk factors

  • Bruising or bleeding

    Bleeding disorder

    ...and 1 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

  • Lowers kidney function

    Kidney problems

    ...and 5 more risk factors

  • Increased blood pressure

    History of high blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings