Diclofenac vs. Plavix

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Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
How it works
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
  • Osteoarthritis pain
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Plavix (Clopidogrel)
-41% vs. Zorvolex (Diclofenac)
-51% vs. Zorvolex (Diclofenac)
-16% vs. Zorvolex (Diclofenac)
Side effects
  • Constipation 4%
  • Diarrhea 3%
  • Abdominal pain upper 2%
  • Pain in extremity 2%
  • Itching 1%
  • Swelling due to excess fluid 1%
  • Passing gas 1%
More Diclofenac side effects »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
Risk factors for serious side effects
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (Diclofenac) risks & warnings »
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    Pregnancy category
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    No specific alcohol-related info.
    • Take it with food to avoid getting diarrhea.
    No specific food-related info.
    Kidneys and liver
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Available as a generic.
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    Downsides and risks
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    Tips from our pharmacists for people taking the medication
    • Take it with food to avoid getting diarrhea.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
    • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    Learn more
    More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert