Compare Diclofenac vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(Diclofenac)

Plavix
(Clopidogrel)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
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Reviews & ratings
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Have you used Zorvolex (Diclofenac)?
Worth itNot sureNot worth it
Reviews for Plavix (Clopidogrel)
59%
41% vs. Zorvolex (Diclofenac)
49%
51% vs. Zorvolex (Diclofenac)
16%
16% vs. Zorvolex (Diclofenac)
343 reviews
Have you used Plavix (Clopidogrel)?
Worth itNot sureNot worth it
Side effects
DiclofenacPlavix
  • Constipation 4%
  • Diarrhea 3%
  • Abdominal pain upper 2%
  • Pain in extremity 2%
  • Itching 1%
  • Swelling due to excess fluid 1%
  • Passing gas 1%
More Diclofenac side effects »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
How it works
DiclofenacPlavix
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
DiclofenacPlavix
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription only
Anticoagulant
Anti-platelet
Prescription only
Available as
DiclofenacPlavix
  • Pill
  • Pill
Used for (click to learn more)
DiclofenacPlavix
  • Osteoarthritis pain
Risk factors for serious side effects
DiclofenacPlavix
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed risks & warnings »
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
Detailed risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
DiclofenacPlavix
No interactions related info.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
Alcohol
DiclofenacPlavix
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
No alcohol related info.
Food
DiclofenacPlavix
  • Take it with food to avoid getting diarrhea.
No food related info.
Kidneys and liver
DiclofenacPlavix
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
No kidneys and liver related info.
Pain
DiclofenacPlavix
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
No pain related info.
Upsides and benefits
DiclofenacPlavix
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
  • Studies have shown clopidogrel lowers your risk of death or further heart complications.
Downsides and risks
DiclofenacPlavix
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Raises your risk of bleeding and bruising.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Doesn't work well for people with certain genetic variations.
Tips from our pharmacists for people taking the medication
DiclofenacPlavix
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • Can raise your risk of bleeding or bruising.
  • Take it exactly as instructed.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
Learn more
More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zorvolex (Diclofenac)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (Clopidogrel)?
Worth itNot sureNot worth it