Compare Diclofenac vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

diclofenac

Plavix
(clopidogrel)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Prevents blood clots. Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.
Reviews & ratings
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Have you used Zorvolex (Diclofenac)?
Worth itNot sureNot worth it
Reviews for Plavix
59%
+41% better vs. Diclofenac
49%
+51% better vs. Diclofenac
16%
+16% better vs. Diclofenac
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Side effects
DiclofenacPlavix
  • Dyspepsia 1%
  • Flatulence 1%
  • Pain in extremity 2%
  • Pruritus 1%
  • Constipation 4%
  • Edema 1%
More Diclofenac side effects »
  • Major bleeding 1%
  • Minor bleeding 3%
More Plavix side effects »
How it works
DiclofenacPlavix
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Plavix (clopidogrel) is an antiplatelet blood thinner. It stops platelets in your blood from clumping together which makes it harder for them to form clots.
Type of medication
DiclofenacPlavix
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
DiclofenacPlavix
  • Pill
  • Pill
Used for
DiclofenacPlavix
  • Osteoarthritis Pain
Risk factors for serious side effects
DiclofenacPlavix
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Zorvolex (Diclofenac) risks & warnings »
  • Taking Prilosec or Nexium
  • People with certain genes that make Plavix (clopidogrel) less effective
  • History of stomach bleeding
  • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
  • Taking other blood thinners or medicines that increase the risk of bleeding
Detailed Plavix (clopidogrel) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
DiclofenacPlavix
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
No alcohol related info.
Food
DiclofenacPlavix
  • Take it with food to avoid getting diarrhea.
No food related info.
Kidneys and liver
DiclofenacPlavix
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
No kidneys and liver related info.
Pain
DiclofenacPlavix
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
No pain related info.
Upsides and benefits
DiclofenacPlavix
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
Downsides and risks
DiclofenacPlavix
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
Tips from our pharmacists for people taking the medication
DiclofenacPlavix
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
  • Thins your blood to prevent clots from forming or getting bigger.
  • Can raise your risk of bleeding or bruising.
  • Take this medicine exactly as told by your doctor.
  • Plavix (clopidogrel) may not be safe to be taken together with some medicines and over-the-counter supplements. Don't start any new medicine without first speaking with your doctor or pharmacist.
  • Let your doctor know right away if you experience a fever, weakness, or unusual bleeding and bruising.
  • You should stop taking Plavix (clopidogrel) at least 5 days before any major surgeries to lower your chances of bleeding.
Learn more
More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zorvolex (Diclofenac)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it