Compare Diclofenac vs. Tramadol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(diclofenac)

Ultram
(tramadol)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Treats moderate to severe pain. Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.
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Reviews & ratings
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Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it
Reviews for Ultram (tramadol)
61%
-39% worse vs. Zorvolex (diclofenac)
40%
-60% worse vs. Zorvolex (diclofenac)
16%
-16% worse vs. Zorvolex (diclofenac)
642 reviews
Have you used Ultram (tramadol)?
Worth itNot sureNot worth it
Side effects
DiclofenacTramadol
  • Swelling due to excess fluid 1%
  • Constipation 4%
  • Itching 1%
  • Passing gas 1%
  • Pain in extremity 2%
  • Indigestion 1%
More Diclofenac side effects »
  • Dizziness 26%
  • Constipation 24%
  • Nausea 24%
  • Headache 18%
  • Sleepiness 16%
  • Vomiting 9%
  • Itching 8%
  • Cns stimulation 7%
  • Muscle weakness 6%
  • Sweating 6%
More Tramadol side effects »
How it works
DiclofenacTramadol
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Ultram (tramadol) is an opioid pain reliever. Researchers don't know exactly how it works, but it alters certain brain chemicals to lower pain perception and improve mood.
Type of medication
DiclofenacTramadol
Prescription only
Prescription only
Available as
DiclofenacTramadol
  • Pill
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
Used for
DiclofenacTramadol
  • Osteoarthritis Pain
Risk factors for serious side effects
DiclofenacTramadol
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 65 years or older
  • Bleeding disorder
  • Taking other blood-thinning medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney problems
  • Heart failure
  • Liver disease
  • Taking diuretics
  • Taking ACE inhibitors or angiotensin receptor blockers (ARBs)
  • Age 65 or older
  • History of high blood pressure
  • Taking water pills (diuretics)
Detailed Zorvolex (diclofenac) risks & warnings »
    • Pregnancy
    • Age 65 or greater
    • Overdose
    • Using alcohol, benzodiazepines or other medicines that slow breathing
    • Taking more than the prescribed dose
    • Taking with alcohol or benzodiazepines
    • Stopping Ultram (tramadol) suddenly
    • Children can reach medication
    Detailed Ultram (tramadol) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    DiclofenacTramadol
    No interactions related info.
    • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
    Alcohol
    DiclofenacTramadol
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    No alcohol related info.
    Food
    DiclofenacTramadol
    • Take it with food to avoid getting diarrhea.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    Kidneys and liver
    DiclofenacTramadol
    • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    Pain
    DiclofenacTramadol
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
    Upsides and benefits
    DiclofenacTramadol
    • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
    • Can be used as needed to treat pain and swelling.
    • Available as a generic.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
    • Has a lower chance of causing breathing problems compared to other typical opioids.
    • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
    Downsides and risks
    DiclofenacTramadol
    • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
    • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
    • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
    • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
    • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
    Tips from our pharmacists for people taking the medication
    DiclofenacTramadol
    • Take it with food to avoid getting diarrhea.
    • Don't drink alcohol while using Zorvolex (Diclofenac).
    • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
    • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
    • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
    • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
    • Starts working in one hour and works best if you take it regularly.
    • Can make you dizzy or drowsy, so avoid activities that need you to be fully alert until you know how this medicine affects you.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    • Swallow the extended-release tablets whole. They're designed to release the drug slowly and breaking, crushing, or chewing them could cause a serious overdose.
    • Take the extended-release tablets exactly as your doctor and pharmacist tell you. If you forget, take it as soon as you remember. Don't take extra medicine to make up for a missed dose.
    Learn more
    More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zorvolex (diclofenac)?
    Worth itNot sureNot worth it
    More about TramadolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Ultram (tramadol)?
    Worth itNot sureNot worth it