Compare Diclofenac vs. Tylenol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zorvolex
(diclofenac)

Tylenol Regular Strength
(acetaminophen)

Treats arthritis pain and swelling. Zorvolex (Diclofenac) is an okay medication used to treat pain and swelling caused by arthritis. However, because of the risk of heart attack, you should limit the amount you take.Relieves pain and fever. Tylenol Regular Strength (acetaminophen) effectively reduces fever and relieves pain, but it doesn't lower inflammation and swelling.
Reviews & ratings
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Have you used Zorvolex (diclofenac)?
Worth itNot sureNot worth it
Reviews for Tylenol
77%
+23% better vs. Diclofenac
37%
+63% better vs. Diclofenac
3%
+3% better vs. Diclofenac
1002 reviews
Have you used Tylenol Regular Strength (acetaminophen)?
Worth itNot sureNot worth it
Side effects
DiclofenacTylenol
  • Swelling due to excess fluid 1%
  • Constipation 4%
  • Itching 1%
  • Passing gas 1%
  • Pain in extremity 2%
  • Indigestion 1%
More Diclofenac side effects »

The Tylenol FDA package insert doesn’t have numbers about how common side effects are.

More about Tylenol side effects »
How it works
DiclofenacTylenol
Zorvolex (Diclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It stops your body from making chemicals that cause inflammation and pain.Tylenol Regular Strength (acetaminophen) is an analgesic. It relieves pain and lowers fever by stopping the production of certain chemicals in the brain that cause both pain and fever.
Type of medication
DiclofenacTylenol
Prescription onlyOver-the-counter
Available as
DiclofenacTylenol
  • Pill
  • Pill
  • Chewable tablet
  • Dissolving tablet
  • Liquid
  • Suppository
  • Injection
Used for
DiclofenacTylenol
  • Osteoarthritis Pain
Risk factors for serious side effects
DiclofenacTylenol
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Zorvolex (diclofenac) risks & warnings »
  • Medication administering errors
  • Injection formulation
  • Exceeding the recommended maximum daily limits
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
Detailed Tylenol Regular Strength (acetaminophen) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
DiclofenacTylenol
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
Food
DiclofenacTylenol
  • Take it with food to avoid getting diarrhea.
No food related info.
Kidneys and liver
DiclofenacTylenol
  • Zorvolex (Diclofenac), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk of kidney problems. It's important to get lab tests to check your kidney function periodically if you use Zorvolex (Diclofenac) for long periods of time.
  • Taking too much acetaminophen causes liver damage that can be permanent and life-threatening. Signs of liver problems may include dark urine, feeling tired, upset stomach or stomach pain, or yellow skin or eyes. If you notice any of these symptoms, call your doctor immediately. Avoid drinking alcohol when taking Tylenol Regular Strength (acetaminophen). Avoid using Tylenol Regular Strength (acetaminophen) if you have existing liver problems since it can cause further damage.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
Pain
DiclofenacTylenol
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Works well to relieve pain and fevers.
Upsides and benefits
DiclofenacTylenol
  • Clinical studies show that Zorvolex (Diclofenac) is better at relieving arthritis pain than acetaminophen (Tylenol).
  • Can be used as needed to treat pain and swelling.
  • Available as a generic.
  • Works well to relieve pain and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Tylenol Regular Strength (acetaminophen) causes less upset stomach, ulcers, bruising, and bleeding than other pain medications like aspirin and Advil.
  • Doesn't cause kidney damage and is also safe to use if you have heart problems or if you're pregnant.
  • Tylenol Regular Strength (acetaminophen) has been used for a long time and is generally safe for short-term use.
Downsides and risks
DiclofenacTylenol
  • You should avoid alcohol while on Zorvolex (Diclofenac) since it can increase your risk of stomach issues.
  • If you're taking it on a regular basis, you'll need to get labs done to make sure your liver and kidneys aren't being affected.
  • Tylenol Regular Strength (acetaminophen) doesn't treat some kinds of pain as well as other medications like Advil.
  • Drinking alcohol while taking Tylenol Regular Strength (acetaminophen) can damage your liver.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen you are taking since it's a very common ingredient in pain and cold combination medicines.
  • Heavy alcohol drinkers and people with liver problems should avoid using Tylenol Regular Strength (acetaminophen) since it can cause serious liver damage.
Tips from our pharmacists for people taking the medication
DiclofenacTylenol
  • Take it with food to avoid getting diarrhea.
  • Don't drink alcohol while using Zorvolex (Diclofenac).
  • Don't take other anti-inflammatory medications (NSAIDs) without talking to your doctor or pharmacist.
  • Can cause swelling in your legs, abdominal pain, constipation, diarrhea, and an upset stomach.
  • Don't take antacids with magnesium since they can interact with Zorvolex (Diclofenac).
  • Take Zorvolex (Diclofenac) at the smallest dose possible for the shortest amount of time to prevent an increased risk of heart attack.
  • Tylenol Regular Strength (acetaminophen) starts working within one hour.
  • Taking too much of Tylenol Regular Strength (acetaminophen) can cause liver failure and death. Don't take more than what's recommended on the package insert.
  • Acetaminophen is found in many over-the-counter and prescription products. Make sure the total amount of acetaminophen you take does not exceed 3,000 mg per day and check with your pharmacist to make sure you're not taking too much.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about DiclofenacSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zorvolex (diclofenac)?
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More about TylenolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Regular Strength (acetaminophen)?
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