Compare Differen vs. Benzamycin

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(Benzoyl Peroxide / Erythromycin)

Coming soon.Topical treatment for acne. Benzamycin (Benzoyl Peroxide / Erythromycin) is a topical combination acne treatment that may work better for people who didn't see an improvement when taking either medicine alone or simply don't want to take pill medication. You need to be careful because it can bleach your hair, clothing and other fabrics. It also needs to be stored in the refrigerator and is only good for three months..
How it works
Coming soon.Benzamycin (Benzoyl Peroxide / Erythromycin) is a combination topical medicine. Erythromycin (an antibiotic) kills bacteria that cause acne. Benzoyl peroxide works to fight the bacteria and shed acne-affected skin.
Type of medication
Coming soon.
Acne agent
Prescription only
Available as
  • Cream, gel, or ointment
  • Cream, gel, or ointment
Used for (click to learn more)
  • Acne vulgaris
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Reviews & ratings
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Reviews for Benzamycin (Benzoyl Peroxide / Erythromycin)
+21% vs. Differen (Adapalene)
7% vs. Differen (Adapalene)
+21% vs. Differen (Adapalene)
Side effects

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »

The Benzamycin FDA package insert doesn’t have numbers about how common side effects are.

More about Benzamycin side effects »
Risk factors for serious side effects
Coming soon.
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      • Long-term use of Benzamycin (Benzoyl Peroxide / Erythromycin)
      Detailed Benzamycin (Benzoyl Peroxide / Erythromycin) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.
      • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
      Upsides and benefits
      Coming soon.
      • Benzamycin works better to reduce bacteria in oil glands and improve overall signs and symptoms of acne than either medicine alone.
      • Reduces bacteria on the skin, which "calms" the skin down (lowers the inflammatory response) in acne.
      • Combining an antibiotic with benzoyl peroxide lowers the chances of Benzamycin not working as well over time.
      • Although Benzamycin can irritate the skin, a true skin allergy is rare.
      • Can be used in combination with acne pill medicine if your doctor thinks you need it.
      Downsides and risks
      Coming soon.
      • There's a risk of irritation with anything you apply to your skin and this is no different. Benzamycin, contains a topical antibiotic and can cause redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
      • Can cause severe inflammation of the large intestine (pseudomembranous colitis).
      • Not the best choice if you're pregnant. Benzamycin is categorized as pregnancy Category C (weight risks vs benefits) because of the benzoyl peroxide part.
      • Can cause bleaching of hair and clothing.
      • You'll need to stay out of the sun or apply a sunscreen if you go outdoors.
      Tips from our pharmacists for people taking the medication
      Coming soon.
      • Combination medicine you apply to your skin to treat acne.
      • Apply a thin film to clean and dry affected skin twice a day- in the morning and evening.
      • Store in the refrigerator, but don't freeze.
      • The pharmacist mixes the medicine when you pick it up at the drugstore. You'll need to use it within three months of this date or dispose of it properly.
      • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      Learn more
      More about DifferenSide effectsReviews & ratingsFDA package insert
      More about BenzamycinSide effectsReviews & ratingsAlternativesFDA package insert