Compare Differen vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Coming soon.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Differen
Best available price for 45 (45g of 0.1%) tube of gels of adapalene
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Differen (adapalene)?
Worth itNot sureNot worth it
Reviews for Doxycycline
-16% worse vs. Differen
-3% worse vs. Differen
-9% worse vs. Differen
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
How it works
Coming soon.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
Prescription only
Available as
  • Cream, gel, or ointment
  • Pill
  • Delayed release capsule
  • Liquid
Used for
  • Acne Vulgaris
Risk factors for serious side effects
    Coming soon.
    • Age 8 years or younger
    • Using oral birth control pills
    • Long antibiotic treatment period
    • Women of childbearing age
    Detailed Vibramycin (doxycycline) risks & warnings »

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Upsides and benefits
    Coming soon
    • Available in generic.
    • Available in different forms: tablet, capsule, and suspension.
    • Used to treat many types of bacterial infections.
    • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
    Downsides and risks
    Coming soon
    • Can't be used in pregnant women and children under 8 years old.
    • Makes your skin more sensitive to the sun.
    • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
    • Can make birth control less effective.
    • Can cause diarrhea.
    Tips from our pharmacists for people taking the medication
    Coming soon
    • Take the medication exactly how your doctor tells you to.
    • If you're using birth control pills, this medication can make them less effective.
    • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
    • Can cause diarrhea, nausea or vomiting.
    • Space out any vitamins by at least two hours.
    • Take with plenty of food and liquids.
    • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
    • Don't lie down for at least 30 minutes after taking this medication.
    Learn more
    More about DifferenSide effectsReviews & ratingsFDA package insert
    Have you used Differen (adapalene)?
    Worth itNot sureNot worth it
    More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Vibramycin (doxycycline)?
    Worth itNot sureNot worth it