Compare Differen vs. doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Differen (Adapalene)

Vibramycin (doxycycline)

Prescription only
No information currently available
Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

4.3/ 7 average rating with 112 reviewsfordoxycycline
Upsides
No information currently available
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
Downsides
No information currently available
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
Used for
Dosage forms
  • Cream, gel, or ointment
  • Pill
  • Delayed release pill
  • Liquid
Price
Lowest price near you
$57.15
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Lowest price near you
$36.81
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Reviews
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112 
49%
think this treatment is worth it
36%
think this treatment works well
24%
think this treatment is a hassle

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Side effects
The Differen (Adapalene) FDA package insert doesn’t have numbers about how common side effects are.
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
No information currently available
  • Color changes in teeth of young children and unborn babies

    Age 8 or younger

    ...and 2 more risk factors

  • Severe diarrhea

    Using Vibramycin (doxycycline) for a long period of time

  • Sunburn or rash

    Being in the sun for a long period of time

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Women who can potentially or want to become pregnant

    ...and 1 more risk factors

See more detailed risks and warnings