Compare Differen vs. Doxycycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Differen
(Adapalene)

Vibramycin
(Doxycycline)

Coming soon.Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.
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Have you used Differen (Adapalene)?
Worth itNot sureNot worth it
Reviews for Vibramycin (Doxycycline)
50%
+17% vs. Differen (Adapalene)
34%
+1% vs. Differen (Adapalene)
23%
+10% vs. Differen (Adapalene)
103 reviews
Have you used Vibramycin (Doxycycline)?
Worth itNot sureNot worth it
Side effects
DifferenDoxycycline

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »
How it works
DifferenDoxycycline
Coming soon.Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DifferenDoxycycline
Coming soon.
Antibiotic
Tetracycline
Prescription only
Available as
DifferenDoxycycline
  • Cream, gel, or ointment
  • Pill
  • Delayed release capsule
  • Liquid
Used for (click to learn more)
DifferenDoxycycline
  • Acne vulgaris
Risk factors for serious side effects
DifferenDoxycycline
Coming soon.
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
      Pregnancy category
      DifferenDoxycycline
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol related info.
      Food
      No specific food related info.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Take with plenty of food and liquids.
      Sex
      No specific sex related info.
      Upsides and benefits
      DifferenDoxycycline
      Coming soon.
      • Available in generic.
      • Available in different forms: tablet, capsule, and suspension.
      • Used to treat many types of bacterial infections.
      • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
      Downsides and risks
      DifferenDoxycycline
      Coming soon.
      • Can't be used in pregnant women and children under 8 years old.
      • Makes your skin more sensitive to the sun.
      • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
      • Can make birth control less effective.
      • Can cause diarrhea.
      Tips from our pharmacists for people taking the medication
      DifferenDoxycycline
      Coming soon.
      • Take the medication exactly how your doctor tells you to.
      • If you're using birth control pills, this medication can make them less effective.
      • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
      • Can cause diarrhea, nausea or vomiting.
      • Space out any vitamins by at least two hours.
      • Take with plenty of food and liquids.
      • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
      • Don't lie down for at least 30 minutes after taking this medication.
      Learn more
      More about DifferenSide effectsReviews & ratingsFDA package insert
      Have you used Differen (Adapalene)?
      Worth itNot sureNot worth it
      More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Vibramycin (Doxycycline)?
      Worth itNot sureNot worth it