Compare Differen vs. Erygel

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Topical treatment for acne.

Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.

3.4/ 5 average rating with 93 reviewsforErygel
Upsides
No information currently available
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
Downsides
No information currently available
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
Used for
  • Acne vulgaris
Dosage forms
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Topical solution
Price
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Reviews
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93 reviews so far
46%
saidit'sworth it
34%
saiditworked well
19%
saidit'sa big hassle

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Side effects
The Differen (Adapalene) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Burning
    25%
See more detailed side effects
Risks and risk factors
No information currently available
  • Allergic reaction
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Development of more serious infections
See more detailed risks and warnings