Compare Differen vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Differen
(adapalene)

Akne-Mycin
(erythromycin)

Coming soon.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Coupons for Differen
Best available price for 1 (45g of 0.1%) tube of gel of adapalene
Coupons for Erygel
Best available price for 1 (30g of 2%) tube of gel of erythromycin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Differen (adapalene)
Not enough review data. Review it!
of people (All ages) say Differen (adapalene) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Differen (adapalene)?
Worth itNot sureNot worth it
Reviews for Akne-Mycin (erythromycin)
46%
+13% better vs. Differen (adapalene)
34%
+1% better vs. Differen (adapalene)
19%
+14% better vs. Differen (adapalene)
Have you used Akne-Mycin (erythromycin)?
Worth itNot sureNot worth it
Side effects
DifferenErygel

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »
  • Burning 25%
More Erygel side effects »
How it works
DifferenErygel
Coming soon.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
DifferenErygel
Prescription only
Available as
DifferenErygel
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Topical solution
Used for
DifferenErygel
  • Acne Vulgaris
Risk factors for serious side effects
DifferenErygel
    Coming soon.
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
    Detailed Akne-Mycin (erythromycin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Pain
    DifferenErygel
    No pain related info.
    • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
    Weight
    DifferenErygel
    No weight related info.
    • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
    Upsides and benefits
    DifferenErygel
    Coming soon
    • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
    • Available in a gel formulation which may be better if your skin is very oily.
    • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
    Downsides and risks
    DifferenErygel
    Coming soon
    • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
    • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
    • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
    • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
    • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
    Tips from our pharmacists for people taking the medication
    DifferenErygel
    Coming soon
    • Very commonly used topical antibiotic to treat acne.
    • The only topical erythromycin in a gel formula.
    • Apply a thin film to clean and dry affected skin once or twice a day.
    • It may take 6-8 weeks before you see improvement in your acne.
    • Avoid getting into your eyes, nose or mouth.
    • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
    • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
    • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
    Learn more
    More about DifferenSide effectsReviews & ratingsFDA package insert
    Have you used Differen (adapalene)?
    Worth itNot sureNot worth it
    More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Akne-Mycin (erythromycin)?
    Worth itNot sureNot worth it