Compare Differen vs. Erygel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Differen
(Adapalene)

Akne-Mycin
(Erythromycin)

Coming soon.Topical treatment for acne. Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.
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Reviews & ratings
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Reviews for Akne-Mycin (Erythromycin)
46%
+13% vs. Differen (Adapalene)
34%
+1% vs. Differen (Adapalene)
20%
+13% vs. Differen (Adapalene)
Side effects
DifferenErygel

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »

The Erygel FDA package insert doesn’t have numbers about how common side effects are.

More about Erygel side effects »
How it works
DifferenErygel
Coming soon.Akne-Mycin (Erythromycin) is a topical antibiotic. It fights bacteria that cause acne in oil (sebaceous) glands, and contains alcohol which dries out acne-affected areas.
Type of medication
DifferenErygel
Coming soon.
Acne agent
Antibiotic
Prescription only
Available as
DifferenErygel
  • Cream, gel, or ointment
  • Cream, gel, or ointment
  • Topical solution
Used for (click to learn more)
DifferenErygel
  • Acne vulgaris
Risk factors for serious side effects
DifferenErygel
Coming soon.
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
      Detailed Akne-Mycin (Erythromycin) risks & warnings »
      Pregnancy category
      DifferenErygel
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      DifferenErygel
      Coming soon.
      • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
      • Available in a gel formulation which may be better if your skin is very oily.
      • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
      Downsides and risks
      DifferenErygel
      Coming soon.
      • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
      • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
      • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
      • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
      • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
      Tips from our pharmacists for people taking the medication
      DifferenErygel
      Coming soon.
      • Very commonly used topical antibiotic to treat acne.
      • The only topical erythromycin in a gel formula.
      • Apply a thin film to clean and dry affected skin once or twice a day.
      • It may take 6-8 weeks before you see improvement in your acne.
      • Avoid getting into your eyes, nose or mouth.
      • Let your doctor know if you notice abdominal discomfort, pain or diarrhea after starting this medicine.
      • Using a moisturizer that doesn't block your pores (non-comedogenic) may help lessen common side effects of skin dryness and peeling.
      • Taking good care of your skin is an important part of treating acne. Lightly wash with warm water and non-soap-based or gentle cleanser.
      Learn more
      More about DifferenSide effectsReviews & ratingsFDA package insert
      More about ErygelSide effectsReviews & ratingsAlternativesFDA package insert