Compare Differen vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Differen
(Adapalene)

Solodyn
(Minocycline)

Coming soon.Treats bacterial infections. Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.
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Reviews & ratings
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Have you used Differen (Adapalene)?
Worth itNot sureNot worth it

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Have you used Solodyn (Minocycline)?
Worth itNot sureNot worth it
Side effects
DifferenMinocycline

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »

We haven’t found good data for Minocycline side effects.

FDA side effect reports for Minocycline »
How it works
DifferenMinocycline
Coming soon.Solodyn (Minocycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.
Type of medication
DifferenMinocycline
Coming soon.
Antibiotic
Tetracycline
Prescription only
Available as
DifferenMinocycline
  • Cream, gel, or ointment
  • Pill
  • Extended release
  • Extended release capsule
Used for (click to learn more)
DifferenMinocycline
  • Acne vulgaris
Risk factors for serious side effects
DifferenMinocycline
Coming soon.
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      Detailed Solodyn (Minocycline) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Upsides and benefits
      DifferenMinocycline
      Coming soon
      • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
      • Available as a generic, so it should be reasonably priced.
      • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
      • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
      Downsides and risks
      DifferenMinocycline
      Coming soon
      • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
      • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
      Tips from our pharmacists for people taking the medication
      DifferenMinocycline
      Coming soon
      • Both men and women should use barrier methods of birth control while on Solodyn (Minocycline) since it can cause birth defects and make birth control pills less effective.
      • Can make you dizzy, so be careful if you're getting up from lying down or sitting. Don't drive until you know how it affects you.
      • Can stain your teeth, tongue and gums, but this is temporary.
      • Take this exactly how your doctor or pharmacist tells you until it's all gone.
      • Don't eat any dairy products or take any vitamins within 2 hours of taking Solodyn (Minocycline) because they can make the medication less effective.
      Learn more
      More about DifferenSide effectsReviews & ratingsFDA package insert
      Have you used Differen (Adapalene)?
      Worth itNot sureNot worth it
      More about MinocyclineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Solodyn (Minocycline)?
      Worth itNot sureNot worth it