Compare Differen vs. Renova

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Coming soon.Treats acne and sun damage. Renova (Tretinoin) isn't a cure for fine lines and wrinkles, but it's clinically proven to improve them.
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Reviews & ratings
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Reviews for Renova (Tretinoin)
+7% vs. Differen (Adapalene)
7% vs. Differen (Adapalene)
+5% vs. Differen (Adapalene)
Side effects

We haven’t found good data for Differen side effects.

FDA side effect reports for Differen »
  • Severe local irritation 6%
More Renova side effects »
How it works
Coming soon.Renova (Tretinoin) is a vitamin A derivative. Researchers don't know exactly how it works, but it seems to make skin cells renew faster and better.
Type of medication
Coming soon.
Acne agent
Prescription only
Available as
  • Cream, gel, or ointment
  • Cream, gel, or ointment
Used for (click to learn more)
  • Acne vulgaris
Risk factors for serious side effects
Coming soon.
  • Using other medicines or products that irritate the skin
  • Eczema
  • Extreme temperatures (hot or cold)
    • Allergy to fish or fish products
      Detailed Renova (Tretinoin) risks & warnings »
      Pregnancy category
      No specific alcohol-related info.No specific alcohol-related info.
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      No specific sleep-related info.No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Coming soon.
      • You only need to apply it once a day, usually in the evening.
      • Most people who reported having skin irritation said that it was mild.
      • Part of a complete program to help you take better care of your skin.
      Downsides and risks
      Coming soon.
      • It may take up to 6 months to see the full benefit for facial wrinkles.
      • Not a good choice for women who want to become or are pregnant
      • Can change the color and texture of your skin if used long-term.
      • You need to be careful about avoiding any sunlight or artificial tanning while using it.
      • It doesn't work for deep wrinkles.
      Tips from our pharmacists for people taking the medication
      Coming soon.
      • Works best as part of a complete skin care program (including SPF) to protect your skin from sun damage.
      • Renova doesn't permanently erase or improve significant skin changes such as deep wrinkles.
      • Apply a very small amount (pea-size) on entire face once a day at bedtime.
      • You'll need to use Renova regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
      • Renova wasn't studied in people with skin cancer or serious damage from the sun (actinic keratosis) so it's not known if this would benefit.
      • Not safe to use during pregnancy. Even though Renova is applied to the skin, a small amount is absorbed and harmful to your unborn baby.
      • Some medicines you take by mouth can make you more sensitive to sunlight and combine with effects of Renova. Check with your doctor or pharmacist before you take any new medicines.
      Learn more
      More about DifferenSide effectsReviews & ratingsFDA package insert
      More about RenovaSide effectsReviews & ratingsFDA package insert