Compare Dilaudid vs. Fentanyl

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dilaudid (Hydromorphone)

Prescription only

Duragesic (Fentanyl)

Prescription only
Treats moderate to severe pain.

Dilaudid (Hydromorphone) is a fast-acting, potent medication that treats problems needing strong pain relief.

5.6/ 7 average rating with 51 reviewsforDilaudid
Treats severe pain.

Duragesic (Fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.

5.8/ 7 average rating with 84 reviewsforFentanyl
Upsides
  • Works well to relieve moderate to severe pain.
  • Dilaudid (Hydromorphone) is stronger than morphine and works quicker than other pain medications.
  • It doesn't cause as many side effects, like nausea and rashes, as morphine does.
  • It's available as fast-acting tablets, extended-release tablets, and as a liquid.
  • It's used for people who have tried other opioid medications, but still need stronger pain relief.
  • Duragesic (Fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (Fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
Downsides
  • People with breathing problems like asthma and COPD need to be monitored very closely if taking Dilaudid (Hydromorphone).
  • Dilaudid (Hydromorphone) isn't usually used for elderly or frail patients.
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Everyone tends to get constipation while on this, so you'll need to stay hydrated and may need to take a stool softener medication.
  • Long-term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after using it longer than 2 weeks.
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • It doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Shouldn't be used for people with breathing problems (like asthma and COPD), a slow heart rate, or in the elderly.
  • If using the patch, you won't be able to get the medicine out of your body quickly in case of an overdose.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Suppository
  • Patch
  • Patch extended release
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
Price
Lowest price near you
$7.72
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Lowest price near you
$44.07
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Reviews
51 
78%
think this treatment is worth it
65%
think this treatment works well
10%
think this treatment is a hassle

Have you used Dilaudid (Hydromorphone)?

Leave a review
84 
79%
think this treatment is worth it
70%
think this treatment works well
14%
think this treatment is a hassle

Have you used Duragesic (Fentanyl)?

Leave a review
Side effects
10possible side effects
  • Constipation
    31%
  • Nausea
    28%
  • Headache
    15%
  • Somnolence
    14%
  • Asthenia/fatigue
    12%
  • Dizziness
    11%
  • Diarrhea
    11%
  • Pruritus
    8%
  • Insomnia
    8%
  • Hyperhydrosis
    7%
See more detailed side effects
8possible side effects
  • Vomiting
    34%
  • Nausea
    24%
  • Dizziness
    17%
  • Somnolence
    17%
  • Headache
    16%
  • Constipation
    13%
  • Diarrhea
    13%
  • Pruritus
    13%
See more detailed side effects
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings