Compare Dilaudid vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dilaudid (Hydromorphone)

Prescription only

Oxycontin (Oxycodone)

Prescription only
Treats moderate to severe pain.

Dilaudid (Hydromorphone) is a fast-acting, potent medication that treats problems needing strong pain relief.

4.1/ 5 average rating with 51 reviewsforDilaudid
Treats severe pain.

Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.

3.8/ 5 average rating with 1241 reviewsforOxycodone
Upsides
  • Works well to relieve moderate to severe pain.
  • Dilaudid (Hydromorphone) is stronger than morphine and works quicker than other pain medications.
  • It doesn't cause as many side effects, like nausea and rashes, as morphine does.
  • It's available as fast-acting tablets, extended-release tablets, and as a liquid.
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
Downsides
  • People with breathing problems like asthma and COPD need to be monitored very closely if taking Dilaudid (Hydromorphone).
  • Dilaudid (Hydromorphone) isn't usually used for elderly or frail patients.
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Everyone tends to get constipation while on this, so you'll need to stay hydrated and may need to take a stool softener medication.
  • Long-term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after using it longer than 2 weeks.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Suppository
  • Pill
  • Extended release
  • Oral solution
  • Liquid
Price
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Reviews
51 reviews so far
78%
saidit'sworth it
65%
saiditworked well
10%
saidit'sa big hassle

Have you used Dilaudid (Hydromorphone)?

Leave a review
1241 reviews so far
66%
saidit'sworth it
50%
saiditworked well
19%
saidit'sa big hassle

Have you used Oxycontin (Oxycodone)?

Leave a review
Side effects
28possible side effects
  • Constipation
    31%
  • Nausea
    28%
  • Headache
    15%
  • Somnolence
    14%
  • Asthenia/fatigue
    12%
  • Dizziness
    11%
  • Diarrhea
    11%
  • Pruritus
    8%
  • Insomnia
    8%
  • Hyperhydrosis
    7%
  • Edema peripheral
    6%
  • Dry mouth
    6%
  • Anorexia/decreased appetite
    5%
  • Abdominal pain
    5%
  • Anxiety
    5%
  • Back pain
    4%
  • Dyspepsia
    4%
  • Depression
    3%
  • Dyspnea
    3%
  • Muscle spasms
    3%
  • Arthralgia
    3%
  • Rash
    3%
  • Pain in extremity
    3%
  • Pain
    2%
  • Drug withdrawal syndrome
    2%
  • Pyrexia
    2%
  • Fall
    2%
  • Chest pain
    2%
See more detailed side effects
20possible side effects
  • Abdominal pain
    5%
  • Diarrhea
    5%
  • Dyspepsia
    5%
  • Gastritis
    5%
  • Chills
    5%
  • Fever
    5%
  • Anorexia
    5%
  • Twitching
    5%
  • Abnormal dreams
    5%
  • Anxiety
    5%
  • Confusion
    5%
  • Dysphoria
    5%
  • Euphoria
    5%
  • Insomnia
    5%
  • Nervousness
    5%
  • Thought abnormalities
    5%
  • Dyspnea
    5%
  • Hiccups
    5%
  • Rash
    5%
  • Postural hypotension
    5%
See more detailed side effects
Risks and risk factors
  • Death from lack of oxygen to the body (respiratory depression)
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Low blood pressure
    • Age 65 years or older
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Low blood pressure
    • Age 65 years or older
  • Severe allergic reactions
  • Death from overdose (oral concentrate)
See more detailed risks and warnings