Compare Dilaudid vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dilaudid
(hydromorphone)

Percocet
(oxycodone / acetaminophen)

Treats moderate to severe pain. Dilaudid (Hydromorphone) is a fast-acting, potent medication that treats problems needing strong pain relief.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.59Dilaudid
Reviews for Dilaudid
78%
of people (All ages) say Dilaudid is worth it
65%
say it works well
10%
say it's a big hassle
Have you used Dilaudid (hydromorphone)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
+8% better vs. Dilaudid
49%
+16% better vs. Dilaudid
15%
+5% better vs. Dilaudid
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
DilaudidPercocet
  • Constipation 15%
  • Nausea 12%
  • Somnolence 9%
  • Headache 8%
  • Vomiting 2%
  • Arthralgia 4%
  • Pruritus 5%
  • Insomnia 1%
  • Asthenia/fatigue 12%
  • Dizziness 11%
More Dilaudid side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
DilaudidPercocet
Dilaudid (Hydromorphone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
DilaudidPercocet
Prescription onlyPrescription only
Available as
DilaudidPercocet
  • Pill
  • Extended release
  • Oral solution
  • Suppository
  • Pill
  • Oral solution
Used for
DilaudidPercocet
Risk factors for serious side effects
DilaudidPercocet
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Dilaudid (hydromorphone) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
DilaudidPercocet
  • Never use alcohol when taking Dilaudid (Hydromorphone).
  • Avoid alcohol.
Food
DilaudidPercocet
No food related info.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
DilaudidPercocet
No kidneys and liver related info.
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
DilaudidPercocet
  • Works well to relieve moderate to severe pain.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
Sleep
DilaudidPercocet
  • Dilaudid (Hydromorphone) will cause drowsiness, so be really careful if you're taking other meds that also cause drowsiness, such as antidepressives, antianxiety meds, or muscle relaxants.
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
DilaudidPercocet
  • Works well to relieve moderate to severe pain.
  • Dilaudid (Hydromorphone) is stronger than morphine and works quicker than other pain medications.
  • It doesn't cause as many side effects, like nausea and rashes, as morphine does.
  • It's available as fast-acting tablets, extended-release tablets, and as a liquid.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
DilaudidPercocet
  • People with breathing problems like asthma and COPD need to be monitored very closely if taking Dilaudid (Hydromorphone).
  • Dilaudid (Hydromorphone) isn't usually used for elderly or frail patients.
  • Dizziness and drowsiness are common when taking Dilaudid (Hydromorphone), but your body may adjust over time.
  • Everyone tends to get constipation while on this, so you'll need to stay hydrated and may need to take a stool softener medication.
  • Long-term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after using it longer than 2 weeks.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
DilaudidPercocet
  • Dilaudid (Hydromorphone) is usually taken for a short time. If you take it longer than 2 weeks, you'll need to lower your dose slowly to get off it since stopping suddenly can cause withdrawal symptoms.
  • Usually works within 30 minutes.
  • Dilaudid (Hydromorphone) will cause drowsiness, so be really careful if you're taking other meds that also cause drowsiness, such as antidepressives, antianxiety meds, or muscle relaxants.
  • Never use alcohol when taking Dilaudid (Hydromorphone).
  • It's very important to keep Dilaudid (Hydromorphone) away from children, since it can stop them from breathing.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
Learn more
More about DilaudidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dilaudid (hydromorphone)?
Worth itNot sureNot worth it
More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it