Compare Diltiazem vs. Calan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Calan
(Verapamil)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Verapamil works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.757575757575758Diltiazem
Reviews for Cardizem (Diltiazem)
53%
of people (All ages) say Cardizem (Diltiazem) is worth it
48%
say it works well
16%
say it's a big hassle
Have you used Cardizem (Diltiazem)?
Worth itNot sureNot worth it
Reviews for Calan (Verapamil)
33%
20% vs. Cardizem (Diltiazem)
31%
17% vs. Cardizem (Diltiazem)
21%
5% vs. Cardizem (Diltiazem)
Have you used Calan (Verapamil)?
Worth itNot sureNot worth it
Side effects
DiltiazemCalan
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »

The Calan FDA package insert doesn’t have numbers about how common side effects are.

More about Calan side effects »
How it works
DiltiazemCalan
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Verapamil is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.
Type of medication
DiltiazemCalan
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Calcium channel blocker
Prescription only
Available as
DiltiazemCalan
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
  • Extended release
  • Delayed release capsule
Used for (click to learn more)
DiltiazemCalan
Risk factors for serious side effects
DiltiazemCalan
    • Taking digoxin or beta-blockers at the same time
    • History of liver disease
    Detailed Cardizem (Diltiazem) risks & warnings »
    • Severe left ventricular dysfunction (ejection fraction <30%)
    • Taking beta-blockers
      • History of liver disease
      • History of kidney disease
      • History of liver disease
      Detailed Calan (Verapamil) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      DiltiazemCalan
      • Interacts with the cholesterol medicine Simvastatin.
      • Interacts with grapefruit and the cholesterol medicine Simvastatin.
      Alcohol
      DiltiazemCalan
      • Not a good medication for you if you drink alcohol.
      • Not a good medication for you if you drink alcohol.
      • Don't drink too much alcohol while taking this medicine.
      Kidneys and liver
      DiltiazemCalan
      • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
      • Your doctor may check your liver regularly, as there have been reports of liver damage which can only be seen through blood tests. If you do have a history of liver disease, let your doctor know.
      • Your doctor may monitor your heart to see if changes to its electrical system may occur, especially if you have had liver or kidney disease in the past.
      Upsides and benefits
      DiltiazemCalan
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      Downsides and risks
      DiltiazemCalan
      • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
      • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Not a good medication for you if you drink alcohol.
      • Women are more likely to have side effects (especially swelling) from Verapamil than men.
      • You can't miss doses. Stopping Verapamil suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Not a good medication for you if you drink alcohol.
      Tips from our pharmacists for people taking the medication
      DiltiazemCalan
      • Can cause dizziness or fatigue in the first few days.
      • Interacts with the cholesterol medicine Simvastatin.
      • Can cause ankle or foot swelling.
      • Can cause gum overgrowth. Ask your dentist to check for this side effect.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Interacts with grapefruit and the cholesterol medicine Simvastatin.
      • Can cause constipation and headache.
      • Don't drink too much alcohol while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Cardizem (Diltiazem)?
      Worth itNot sureNot worth it
      More about CalanSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Calan (Verapamil)?
      Worth itNot sureNot worth it