Compare Diltiazem vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(diltiazem)

Microzide
(hydrochlorothiazide )

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Reviews & ratings
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4.71Diltiazem
Reviews for Cardizem (diltiazem)
52%
of people (All ages) say Cardizem (diltiazem) is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
Reviews for Microzide (hydrochlorothiazide )
47%
-5% worse vs. Cardizem (diltiazem)
31%
-18% worse vs. Cardizem (diltiazem)
16%
Same vs. Cardizem (diltiazem)
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Diltiazemhydrochlorothiazide
  • Swelling due to excess fluid 5%
  • Headache 5%
  • Dizziness 4%
  • Muscle weakness 3%
  • First degree av block 2%
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Diltiazemhydrochlorothiazide
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Diltiazemhydrochlorothiazide
Prescription only
Prescription only
Available as
Diltiazemhydrochlorothiazide
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for
Diltiazemhydrochlorothiazide
Risk factors for serious side effects
Diltiazemhydrochlorothiazide
    • Taking digoxin or beta-blockers at the same time
    • History of liver disease
    Detailed Cardizem (diltiazem) risks & warnings »
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
    • History of sulfa or penicillin allergies
    • Diabetes
    Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Interactions
    Diltiazemhydrochlorothiazide
    • Interacts with the cholesterol medicine Simvastatin.
    No interactions related info.
    Alcohol
    Diltiazemhydrochlorothiazide
    • Not a good medication for you if you drink alcohol.
    No alcohol related info.
    Kidneys and liver
    Diltiazemhydrochlorothiazide
    • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
    • Requires routine blood tests to check kidney function.
    Upsides and benefits
    Diltiazemhydrochlorothiazide
    • A first-choice blood pressure treatment for many people.
    • Calcium channel blockers work especially well for African Americans to lower blood pressure.
    • You can take it alone or with other medicines to help lower blood pressure.
    • Lowers the risk of heart attack and stroke.
    • Prevents heart-related chest pain (angina) if you take it regularly.
    • Treats certain abnormal heart rhythms.
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    Downsides and risks
    Diltiazemhydrochlorothiazide
    • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
    • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
    • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
    • Not a good medication for you if you drink alcohol.
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    Tips from our pharmacists for people taking the medication
    Diltiazemhydrochlorothiazide
    • Can cause dizziness or fatigue in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Interacts with the cholesterol medicine Simvastatin.
    • Can cause ankle or foot swelling.
    • Can cause gum overgrowth. Ask your dentist to check for this side effect.
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Cardizem (diltiazem)?
    Worth itNot sureNot worth it
    More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it