Compare Diltiazem vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem (Diltiazem)

Prescription only
Lowers blood pressure and controls heart rate.

Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.

4.7/ 7 average rating with 105 reviewsforDiltiazem
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

4.5/ 7 average rating with 139 reviewsforhydrochlorothiazide
Upsides
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Price
No pricing information available
Lowest price near you
$4
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Reviews
105 
52%
think this treatment is worth it
49%
think this treatment works well
16%
think this treatment is a hassle

Have you used Cardizem (Diltiazem)?

Leave a review
139 
47%
think this treatment is worth it
31%
think this treatment works well
16%
think this treatment is a hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
Side effects
6possible side effects
  • Edema
    5%
  • Headache
    5%
  • Dizziness
    4%
  • Asthenia
    3%
  • First degree AV block
    2%
  • Bradycardia
    2%
See more detailed side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Abnormally slow heart rate

    Taking digoxin or beta-blockers at the same time

  • Sudden liver disease

    History of liver disease

See more detailed risks and warnings
  • Dehydration and electrolyte imbalance

    Current electrolyte imbalance

    ...and 2 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Gout

    History of gout

    ...and 1 more risk factors

  • Vision problems

    History of sulfa or penicillin allergies

  • Higher blood sugars

    Diabetes

See more detailed risks and warnings