Compare Diltiazem vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Zestril
(Lisinopril)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Zestril (Lisinopril) is a good blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.71Diltiazem
Reviews for Cardizem (Diltiazem)
52%
of people (All ages) say Cardizem (Diltiazem) is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (Diltiazem)?
Worth itNot sureNot worth it
Reviews for Zestril (Lisinopril)
61%
+9% vs. Cardizem (Diltiazem)
51%
+2% vs. Cardizem (Diltiazem)
14%
+2% vs. Cardizem (Diltiazem)
687 reviews
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it
Side effects
DiltiazemLisinopril
  • Abnormally slow heartbeat 2%
  • Swelling due to excess fluid 2%
More Diltiazem side effects »

The Lisinopril FDA package insert doesn’t have numbers about how common side effects are.

More about Lisinopril side effects »
How it works
DiltiazemLisinopril
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Zestril (Lisinopril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
DiltiazemLisinopril
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
ACE inhibitor
Prescription only
Available as
DiltiazemLisinopril
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for (click to learn more)
DiltiazemLisinopril
Risk factors for serious side effects
DiltiazemLisinopril
  • Taking digoxin or beta-blockers at the same time
  • History of liver disease
Detailed risks & warnings »
  • Women of childbearing age
  • African descent
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DiltiazemLisinopril
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Alcohol
DiltiazemLisinopril
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Kidneys and liver
DiltiazemLisinopril
  • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
Upsides and benefits
DiltiazemLisinopril
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
Downsides and risks
DiltiazemLisinopril
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
DiltiazemLisinopril
  • Can cause dizziness or fatigue in the first few days.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause dizziness in the first few days.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
Learn more
More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cardizem (Diltiazem)?
Worth itNot sureNot worth it
More about LisinoprilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Zestril (Lisinopril)?
Worth itNot sureNot worth it