Compare Diltiazem vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(diltiazem)

Lopressor
(metoprolol tartrate)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Lopressor (metoprolol tartrate) lowers high blood pressure, controls chest pain, and helps treat heart failure and heart attack. You need to take it with food and can't miss a dose.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.71Diltiazem
Reviews for Diltiazem
52%
of people (All ages) say Diltiazem is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
Reviews for Lopressor
62%
-10% worse vs. Diltiazem
47%
+2% better vs. Diltiazem
15%
-1% worse vs. Diltiazem
464 reviews
Have you used Lopressor (metoprolol tartrate)?
Worth itNot sureNot worth it
Side effects
DiltiazemLopressor
  • Swelling due to excess fluid 5%
  • Headache 5%
  • Dizziness 4%
  • Muscle weakness 3%
  • First degree av block 2%
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Itching or skin rash 5%
  • Shortness of breath 3%
  • Slowed heart rate 3%
  • Low blood pressure 4%
More Lopressor side effects »
How it works
DiltiazemLopressor
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Lopressor (metoprolol tartrate) is a beta blocker. It lowers blood pressure by slowing your heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
DiltiazemLopressor
Prescription onlyPrescription only
Available as
DiltiazemLopressor
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for
DiltiazemLopressor
Risk factors for serious side effects
DiltiazemLopressor
  • Taking digoxin or beta-blockers at the same time
  • History of liver disease
Detailed Cardizem (diltiazem) risks & warnings »
  • Suddenly stopping Lopressor (metoprolol tartrate)
  • Coronary artery disease
  • Diabetes
  • Heart failure
  • Major surgery requiring anesthesia
Detailed Lopressor (metoprolol tartrate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DiltiazemLopressor
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Alcohol
DiltiazemLopressor
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Food
DiltiazemLopressor
No food related info.
  • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
Kidneys and liver
DiltiazemLopressor
  • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
No kidneys and liver related info.
Pain
DiltiazemLopressor
No pain related info.
  • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
Upsides and benefits
DiltiazemLopressor
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • A first-choice treatment to prevent chest pain (angina).
  • Makes pain episodes less frequent and makes it easier to be active without having chest pain.
  • A first-choice treatment for people who've had a heart attack.
  • Lopressor (metoprolol tartrate) lowers the risk of death during and after a heart attack.
  • Lopressor (metoprolol tartrate) is cheaper than the extended release version.
Downsides and risks
DiltiazemLopressor
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • You need to take Lopressor (metoprolol tartrate) with food twice a day for it to work best.
  • Taking Lopressor (metoprolol tartrate) may make you feel more tired or out of breath during exercise or your normal daily routines. This gets better for most people, but for some it may not go away.
  • Not a first-choice treatment for high blood pressure, unless you have heart failure or heart disease. It can also be added to other medicines if your blood pressure is still too high.
  • Can hide symptoms of low blood sugar if you're diabetic.
  • You can't miss doses. Stopping Lopressor (metoprolol tartrate) suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
DiltiazemLopressor
  • Can cause dizziness or fatigue in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • You should take Lopressor (metoprolol tartrate) with or after meals.
  • Lopressor (metoprolol tartrate) can make you feel dizzy for the first few days. It can also cause fatigue and headaches.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Don't stop taking this medicine suddenly unless your doctor tells you to.
  • This is the immediate release version of the medication, so it needs to be taken twice a day. It's different from the extended release form: Toprol XL (metoprolol succinate).
Learn more
More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lopressor (metoprolol tartrate)?
Worth itNot sureNot worth it