Compare Diltiazem vs. Lopressor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Lopressor
(Metoprolol Tartrate)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Lopressor (Metoprolol Tartrate) is good for controlling chest pain and treating heart failure and heart attack. You have to take it with food, and you can't miss doses.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.757575757575758Diltiazem
Reviews for Cardizem (Diltiazem)
53%
of people say Cardizem (Diltiazem) is worth it
48%
say it works well
16%
say it's a big hassle
Reviews for Lopressor (Metoprolol Tartrate)
61%
+8% vs. Cardizem (Diltiazem)
46%
2% vs. Cardizem (Diltiazem)
15%
+1% vs. Cardizem (Diltiazem)
Side effects
DiltiazemLopressor
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • First-degree heart block 3%
More Lopressor side effects »
How it works
DiltiazemLopressor
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Lopressor (Metoprolol Tartrate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
DiltiazemLopressor
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
DiltiazemLopressor
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for (click to learn more)
DiltiazemLopressor
Risk factors for serious side effects
DiltiazemLopressor
    • Taking digoxin or beta-blockers at the same time
    • History of liver disease
    Detailed Cardizem (Diltiazem) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      • History of asthma
      Detailed Lopressor (Metoprolol Tartrate) risks & warnings »
      Pregnancy category
      DiltiazemLopressor
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Not a good medication for you if you drink alcohol.
      No specific alcohol-related info.
      Food
      • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
      • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
      • Take it with food.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      DiltiazemLopressor
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      Downsides and risks
      DiltiazemLopressor
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
      • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
      • Not a good medication for you if you drink alcohol.
      • Metoprolol tartrate is the immediate release version of Toprol XL. You have to take Metoprolol tartrate with food for it to work best. (On the other hand, you can take Toprol XL any time.)
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease. As a second choice, your doctor might add it to medicines you're already taking if your blood pressure is still too high.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Metoprolol tartrate suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      Tips from our pharmacists for people taking the medication
      DiltiazemLopressor
      • Can cause dizziness or fatigue in the first few days.
      • Interacts with the cholesterol medicine Simvastatin.
      • Can cause ankle or foot swelling.
      • Can cause gum overgrowth. Ask your dentist to check for this side effect.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Take it with food.
      • Can cause dizziness in the first few days.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • This is the immediate release version. It also comes as an extended release form: Toprol XL (metoprolol succinate).
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
      More about LopressorSide effectsReviews & ratingsAlternativesFDA package insert