Compare Diltiazem vs. Norvasc

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Norvasc
(Amlodipine)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.71Diltiazem
Reviews for Cardizem (Diltiazem)
52%
of people (All ages) say Cardizem (Diltiazem) is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (Diltiazem)?
Worth itNot sureNot worth it
Reviews for Norvasc (Amlodipine)
58%
+6% vs. Cardizem (Diltiazem)
50%
+1% vs. Cardizem (Diltiazem)
15%
+1% vs. Cardizem (Diltiazem)
443 reviews
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
Side effects
DiltiazemNorvasc
  • Abnormally slow heartbeat 2%
  • Swelling due to excess fluid 2%
More Diltiazem side effects »
  • Swelling due to excess fluid 10%
  • Dizziness 1%
More Norvasc side effects »
How it works
DiltiazemNorvasc
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.
Type of medication
DiltiazemNorvasc
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Calcium channel blocker
Prescription only
Available as
DiltiazemNorvasc
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for (click to learn more)
DiltiazemNorvasc
Risk factors for serious side effects
DiltiazemNorvasc
  • Taking digoxin or beta-blockers at the same time
  • History of liver disease
Detailed risks & warnings »
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DiltiazemNorvasc
  • Interacts with the cholesterol medicine Simvastatin.
  • Interacts with the cholesterol medicine Simvastatin.
Alcohol
DiltiazemNorvasc
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Kidneys and liver
DiltiazemNorvasc
  • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
  • Might not be a good choice if you have liver disease.
  • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
Pain
DiltiazemNorvasc
No pain related info.
  • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
Upsides and benefits
DiltiazemNorvasc
  • You can take it alone or with other medicines to help lower blood pressure.
  • Treats certain abnormal heart rhythms.
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
Downsides and risks
DiltiazemNorvasc
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
  • Some people might experience flushing with this medication.
  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
  • Might not be a good choice if you have liver disease.
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
Tips from our pharmacists for people taking the medication
DiltiazemNorvasc
  • Can cause dizziness or fatigue in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
Learn more
More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cardizem (Diltiazem)?
Worth itNot sureNot worth it
More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it