Compare Diltiazem vs. felodipine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(diltiazem)

Plendil
(felodipine)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Plendil (felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.71Diltiazem
Reviews for Diltiazem
52%
of people (All ages) say Diltiazem is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it

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Have you used Plendil (felodipine)?
Worth itNot sureNot worth it
Side effects
Diltiazemfelodipine
  • Swelling due to excess fluid 5%
  • Headache 5%
  • Dizziness 4%
  • Muscle weakness 3%
  • First degree av block 2%
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »
  • Headache 1%
  • Flushing 3%
  • Upset stomach 3%
  • Weakness 1%
  • Colds or flu 2%
  • Runny nose 2%
  • Sneezing 2%
  • Rash 1%
More felodipine side effects »
How it works
Diltiazemfelodipine
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Plendil (felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.
Type of medication
Diltiazemfelodipine
Prescription onlyPrescription only
Available as
Diltiazemfelodipine
  • Pill
  • Extended release
  • Extended release capsule
  • Extended release
Used for
Diltiazemfelodipine
Risk factors for serious side effects
Diltiazemfelodipine
  • Taking digoxin or beta-blockers at the same time
  • History of liver disease
Detailed Cardizem (diltiazem) risks & warnings »
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
Detailed Plendil (felodipine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Diltiazemfelodipine
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Alcohol
Diltiazemfelodipine
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Food
Diltiazemfelodipine
No food related info.
  • Plendil (felodipine) can be taken without food or with a light low fat meal.
Kidneys and liver
Diltiazemfelodipine
  • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
No kidneys and liver related info.
Upsides and benefits
Diltiazemfelodipine
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Plendil (felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
Downsides and risks
Diltiazemfelodipine
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Plendil (felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (felodipine) could cause a sudden spike in blood pressure.
  • Plendil (felodipine) can't be crushed or cut into two.
Tips from our pharmacists for people taking the medication
Diltiazemfelodipine
  • Can cause dizziness or fatigue in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (felodipine).
Learn more
More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
More about felodipineSide effectsAlternativesFDA package insert
Have you used Plendil (felodipine)?
Worth itNot sureNot worth it