Compare Diltiazem vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(diltiazem)

Minipress
(prazosin)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Coupons for Diltiazem
Best available price for 90 (30mg) tablets of diltiazem
Coupons for Prazosin
Best available price for 30 (1mg) capsules of prazosin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.71Diltiazem
Reviews for Diltiazem
52%
of people (All ages) say Diltiazem is worth it
49%
say it works well
16%
say it's a big hassle
105 reviews
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
Reviews for Prazosin
46%
+6% better vs. Diltiazem
29%
+20% better vs. Diltiazem
15%
-1% worse vs. Diltiazem
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it
Side effects
DiltiazemPrazosin
  • Swelling due to excess fluid 5%
  • Headache 5%
  • Dizziness 4%
  • Muscle weakness 3%
  • First degree av block 2%
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »
  • Dizziness 10%
  • Headache 8%
  • Drowsiness 8%
  • Lack of energy 7%
  • Weakness 7%
  • Heart pounding or racing sensation 5%
  • Nausea 5%
More Prazosin side effects »
How it works
DiltiazemPrazosin
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
DiltiazemPrazosin
Prescription onlyPrescription only
Available as
DiltiazemPrazosin
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for
DiltiazemPrazosin
Risk factors for serious side effects
DiltiazemPrazosin
  • Taking digoxin or beta-blockers at the same time
  • History of liver disease
Detailed Cardizem (diltiazem) risks & warnings »
  • Age 65 years or older
Detailed Minipress (prazosin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
DiltiazemPrazosin
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Alcohol
DiltiazemPrazosin
  • Not a good medication for you if you drink alcohol.
No alcohol related info.
Food
DiltiazemPrazosin
No food related info.
  • Take with food or at bedtime to avoid side effects.
Kidneys and liver
DiltiazemPrazosin
  • There have been reports of liver damage within the first eight weeks of Cardizem (Diltiazem), particularly if you have a history of liver disease. Your doctor may monitor your liver.
No kidneys and liver related info.
Sleep
DiltiazemPrazosin
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and nausea.
Upsides and benefits
DiltiazemPrazosin
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides and risks
DiltiazemPrazosin
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Tips from our pharmacists for people taking the medication
DiltiazemPrazosin
  • Can cause dizziness or fatigue in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause drowsiness, headache, dizziness, and nausea.
  • Take with food or at bedtime to avoid side effects.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Recheck your blood pressure 1 week after starting this medicine.
Learn more
More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cardizem (diltiazem)?
Worth itNot sureNot worth it
More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it