Compare Diltiazem vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Minipress
(Prazosin)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Reviews & ratings
Button Group. All currently active
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4.757575757575758Diltiazem
Reviews for Cardizem (Diltiazem)
53%
of people say Cardizem (Diltiazem) is worth it
48%
say it works well
16%
say it's a big hassle
Reviews for Minipress (Prazosin)
43%
10% vs. Cardizem (Diltiazem)
28%
20% vs. Cardizem (Diltiazem)
15%
+1% vs. Cardizem (Diltiazem)
Side effects
DiltiazemPrazosin
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »

The Prazosin FDA package insert doesn’t have numbers about how common side effects are.

More about Prazosin side effects »
How it works
DiltiazemPrazosin
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
DiltiazemPrazosin
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Alpha blocker
Prescription only
Available as
DiltiazemPrazosin
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for (click to learn more)
DiltiazemPrazosin
Risk factors for serious side effects
DiltiazemPrazosin
    • Taking digoxin or beta-blockers at the same time
    • History of liver disease
    Detailed Cardizem (Diltiazem) risks & warnings »
    • Age 65 years or older
    Detailed Minipress (Prazosin) risks & warnings »
    Pregnancy category
    DiltiazemPrazosin
    Alcohol
    • Not a good medication for you if you drink alcohol.
    No specific alcohol-related info.
    Food
    • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
    • Take with food or at bedtime to avoid side effects.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    • Can cause drowsiness, headache, dizziness, and nausea.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    DiltiazemPrazosin
    • A first-choice blood pressure treatment for many people.
    • Calcium channel blockers work especially well for African Americans to lower blood pressure.
    • You can take it alone or with other medicines to help lower blood pressure.
    • Lowers the risk of heart attack and stroke.
    • Prevents heart-related chest pain (angina) if you take it regularly.
    • Treats certain abnormal heart rhythms.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Makes urination easier in men with an enlarged prostate.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    Downsides and risks
    DiltiazemPrazosin
    • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
    • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
    • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
    • Not a good medication for you if you drink alcohol.
    • Not the best medicine to lower blood pressure by itself.
    • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
    • Not preferred for people 65 years or older.
    Tips from our pharmacists for people taking the medication
    DiltiazemPrazosin
    • Can cause dizziness or fatigue in the first few days.
    • Interacts with the cholesterol medicine Simvastatin.
    • Can cause ankle or foot swelling.
    • Can cause gum overgrowth. Ask your dentist to check for this side effect.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause drowsiness, headache, dizziness, and nausea.
    • Take with food or at bedtime to avoid side effects.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Recheck your blood pressure 1 week after starting this medicine.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
    More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert