Compare Diltiazem vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lowers blood pressure and controls heart rate.

Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.

3.5/ 5 average rating with 105 reviewsforDiltiazem
Lowers blood pressure.

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

3.4/ 5 average rating with 294 reviewsforZestoretic
Upsides
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
  • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
  • Not a good medication for you if you drink alcohol.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Used for
Dosage forms
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Price
No pricing information available
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Reviews
105 reviews so far
52%
saidit'sworth it
49%
saiditworked well
16%
saidit'sa big hassle

Have you used Cardizem (Diltiazem)?

Leave a review
294 reviews so far
51%
saidit'sworth it
40%
saiditworked well
17%
saidit'sa big hassle

Have you used Zestoretic (Lisinopril / Hydrochlorothiazide)?

Leave a review
Side effects
6possible side effects
  • Edema
    5%
  • Headache
    5%
  • Dizziness
    4%
  • Asthenia
    3%
  • First degree AV block
    2%
  • Bradycardia
    2%
See more detailed side effects
11possible side effects
  • Dizziness
    8%
  • Headache
    5%
  • Cough
    4%
  • Fatigue
    4%
  • Orthostatic Effects
    3%
  • Diarrhea
    3%
  • Nausea
    2%
  • Upper Respiratory Infection
    2%
  • Muscle Cramps
    2%
  • Asthenia
    2%
  • Paresthesia
    2%
See more detailed side effects
Risks and risk factors
  • Skin rashes
  • Abnormally slow heart rate
    • Taking digoxin or beta-blockers at the same time
  • Sudden liver disease
    • History of liver disease
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Unusual tongue swelling
    • African descent
  • Severe allergic reactions while on dialysis
    • People requiring high flux dialysis
  • Acute kidney failure
    • History of kidney disease
  • Heart problems due to high potassium
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
  • Cough
See more detailed risks and warnings