Compare Diltiazem vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Cardizem
(Diltiazem)

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Lowers blood pressure and controls heart rate. Diltiazem works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding alcohol. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.757575757575758Diltiazem
Reviews for Cardizem (Diltiazem)
53%
of people say Cardizem (Diltiazem) is worth it
48%
say it works well
16%
say it's a big hassle
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
2% vs. Cardizem (Diltiazem)
40%
8% vs. Cardizem (Diltiazem)
17%
1% vs. Cardizem (Diltiazem)
Side effects
DiltiazemZestoretic
  • Abnormally slow heartbeat 2%
More Diltiazem side effects »
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »
How it works
DiltiazemZestoretic
Diltiazem is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
DiltiazemZestoretic
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Available as
DiltiazemZestoretic
  • Pill
  • Extended release
  • Extended release capsule
  • Pill
Used for (click to learn more)
DiltiazemZestoretic
Risk factors for serious side effects
DiltiazemZestoretic
    • Taking digoxin or beta-blockers at the same time
    • History of liver disease
    Detailed Cardizem (Diltiazem) risks & warnings »
    • Women of childbearing age
    • African descent
    • People requiring high flux dialysis
    • History of kidney disease
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
      Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
      Pregnancy category
      DiltiazemZestoretic
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Not a good medication for you if you drink alcohol.
      No specific alcohol-related info.
      Food
      • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Doesn't work as well in people with severe kidney problems.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      DiltiazemZestoretic
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
      • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      Downsides and risks
      DiltiazemZestoretic
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Diltiazem than men.
      • You can't miss doses. Stopping Diltiazem suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Some brands of Diltiazem have to be taken with food, so listen carefully for instructions from your doctor or pharmacist.
      • Not a good medication for you if you drink alcohol.
      • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Makes you urinate more often.
      • Doesn't work as well in people with severe kidney problems.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      DiltiazemZestoretic
      • Can cause dizziness or fatigue in the first few days.
      • Interacts with the cholesterol medicine Simvastatin.
      • Can cause ankle or foot swelling.
      • Can cause gum overgrowth. Ask your dentist to check for this side effect.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about DiltiazemSide effectsReviews & ratingsAlternativesFDA package insert
      More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert