Compare Dipentum vs. Sulfasalazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Dipentum
(olsalazine)

Azulfidine
(sulfasalazine)

Treats ulcerative colitis. Dipentum (olsalazine) controls ulcerative colitis once it's been controlled with other medicines, but you can't use it if you have a flare-up.Reduces inflammation. Azulfidine (Sulfasalazine) is used for moderate to severe inflammatory bowel conditions, and with other meds for treating rheumatoid arthritis.
Reviews & ratings
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Have you used Dipentum (olsalazine)?
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Have you used Azulfidine (sulfasalazine)?
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Side effects
DipentumSulfasalazine
  • Diarrhea 4%
  • Abdominal pain and cramps 3%
  • Nausea 1%
  • Joint pain 1%
  • Bloating 1%
  • Low mood disorder 2%
  • Rash 1%
More Dipentum side effects »

We haven’t found good data for Sulfasalazine side effects.

FDA side effect reports for Sulfasalazine »
How it works
DipentumSulfasalazine
Dipentum (olsalazine) lowers chemicals in the body that cause inflammation which are more common in ulcerative colitis.Azulfidine (Sulfasalazine) is an anti-inflammatory drug that reduces inflammation and pain. It treats inflammatory bowel diseases and rheumatoid arthritis.
Type of medication
DipentumSulfasalazine
Prescription onlyPrescription only
Available as
DipentumSulfasalazine
  • Pill
  • Pill
  • Extended release
Used for
DipentumSulfasalazine
Risk factors for serious side effects
DipentumSulfasalazine
  • Allergy to salicylates
  • History of severe allergies
  • History of asthma
  • History of kidney disease
  • History of liver disease
Detailed Dipentum (olsalazine) risks & warnings »
    Detailed Azulfidine (sulfasalazine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    DipentumSulfasalazine
    • Take with food to avoid stomach upset.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    Kidneys and liver
    DipentumSulfasalazine
    • Rarely, Dipentum (olsalazine) can damage your kidneys. Your doctor might do regular blood tests if you have kidney problems.
    • Severe hypersensitivity reactions can include internal organ involvement, such as hepatitis (liver), nephritis (kidney), myocarditis (heart), blood abnormalities, or pneumonitis (lungs).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    Upsides and benefits
    DipentumSulfasalazine
    • Dipentum (olsalazine) is one of the few medicines you can take for ulcerative colitis by mouth.
    • Dipentum (olsalazine) can stop your symptoms from coming back so often.
    • Dipentum (olsalazine) can be used by itself or taken with a rectal formulation may help provide relief if you have already tried the rectal formulation alone without success.
    • When taken consistently, Azulfidine (Sulfasalazine) can control your symptoms of ulcerative colitis and other bowel diseases.
    • Azulfidine (Sulfasalazine) is usually used in combination with other medications to control rheumatoid arthritis.
    Downsides and risks
    DipentumSulfasalazine
    • It's only used if you don't like enemas and suppositories but it doesn't work as fast, and you have to take more pills.
    • Dipentum (olsalazine) can cause more side effects than other pills for ulcerative colitis. Talk to your doctor about oral alternatives with less side effects.
    • You need to have blood tests every 3 months when taking Azulfidine (Sulfasalazine).
    • Azulfidine (Sulfasalazine) isn't a good option if you have kidney or liver disease.
    • Can't take Azulfidine (Sulfasalazine) if you are allergic to aspirin or sulfa medications.
    • Azulfidine (Sulfasalazine) shouldn't be used if you are breastfeeding.
    Tips from our pharmacists for people taking the medication
    DipentumSulfasalazine
    • Take with food to avoid stomach upset.
    • Use Dipentum (olsalazine) every day, not only when you have pain attacks.
    • Tell your doctor if you're allergic to salicylates such as aspirin before taking Dipentum (olsalazine).
    • Keep taking Dipentum (olsalazine) as directed even if your symptoms are gone after a few days.
    • Tell your doctor if you have had the varicella vaccine in the past 6 weeks.
    • If you are on warfarin, talk to your doctor. You may need to have your blood tests checked more often while on Dipentum (olsalazine).
    • Don't use if you are allergic to sulfa drugs or aspirin.
    • Swallow tablets whole, and take after a meal with a full glass of water.
    • Drink at least six glasses of water daily while on this.
    • Continue to take Azulfidine (Sulfasalazine) even once you feel better.
    • Read the information that come with your medication in the drugstore since there are many conditions you should be aware of before taking Azulfidine (Sulfasalazine).
    • Can cause an orange color in your urine or skin.
    Learn more
    More about DipentumSide effectsAlternativesFDA package insert
    Have you used Dipentum (olsalazine)?
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    More about SulfasalazineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Azulfidine (sulfasalazine)?
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