Compare Divigel vs. Evamist

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Divigel
(estradiol gel)

Evamist
(estradiol spray)

Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.Relieves hot flashes due to menopause. Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
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Coupons for Divigel
Best available price for 30 (30 packets of 1mg gel) cartons of divigel
Reviews & ratings
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Have you used Divigel (estradiol gel)?
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Have you used Evamist (estradiol spray)?
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Side effects
DivigelEvamist
  • Common cold 2%
  • Ear, nose, or throat infection 4%
  • Metrorrhagia 2%
  • Breast tenderness 1%
More Divigel side effects »
  • Headache 3%
  • Breast tenderness 4%
  • Nasopharyngitis (common cold) 3%
  • Nipple pain 2%
  • Back pain 1%
  • Nausea 1%
  • Arthralgia (joint pain) 3%
More Evamist side effects »
How it works
DivigelEvamist
Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.Evamist (Estradiol Spray) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
DivigelEvamist
Prescription onlyPrescription only
Available as
DivigelEvamist
  • Cream, gel, or ointment
  • Spray
Used for
DivigelEvamist
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
DivigelEvamist
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Divigel (estradiol gel) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Evamist (estradiol spray) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
DivigelEvamist
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
Weight
DivigelEvamist
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
DivigelEvamist
  • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for people who don't want to take daily pills.
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
  • Divigel (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
  • Dries faster than topical estrogen gels.
  • Good for people who don't want to take daily pills.
  • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
  • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
  • Very few women had skin irritation from the medicine.
  • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
Downsides and risks
DivigelEvamist
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
DivigelEvamist
  • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
  • Wash your hands well after applying the gel.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
Learn more
More about DivigelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Divigel (estradiol gel)?
Worth itNot sureNot worth it
More about EvamistSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Evamist (estradiol spray)?
Worth itNot sureNot worth it