Compare Divigel vs. Femring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves hot flashes due to menopause.

Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.

Relieves hot flashes and vaginal dryness due to menopause.

Femring (Estradiol Acetate Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

2.6/ 5 average rating with 31 reviewsforFemring
Upsides
  • Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Good for people who don't want to or can't take daily pills.
  • Can take the easy to use, pre-measured packets anywhere.
  • Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
  • In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
  • Femring (Estradiol Acetate Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Femring (Estradiol Acetate Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Femring (Estradiol Acetate Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Femring (Estradiol Acetate Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
Downsides
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
  • Femring (Estradiol Acetate Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Femring (Estradiol Acetate Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
Dosage forms
  • Gel
  • Vaginal ring
Price
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Reviews
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31 reviews so far
39%
saidit'sworth it
16%
saiditworked well
19%
saidit'sa big hassle

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Side effects
5possible side effects
  • Breast pain
    6%
  • Unusual vaginal bleeding
    6%
  • Common cold
    4%
  • Lung infection
    2%
  • Yeast infection
    2%
See more detailed side effects
8possible side effects
  • Intermenstrual Bleeding
    8%
  • Headache
    7%
  • Abdominal Distension
    7%
  • Vaginal Candidiasis
    6%
  • Breast Tenderness
    6%
  • Back Pain
    6%
  • Sinusitis
    2%
  • Uterine Pain
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings