Compare Doxepin vs. Butisol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Butisol
(butabarbital)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Helps you fall asleep. Butisol (butabarbital) is not very good for sleeping problems because it can be addictive.
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Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for Butisol
Best available price for 30 (30mg) tablets of butisol
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Butisol (butabarbital)?
Worth itNot sureNot worth it
Side effects
DoxepinButisol

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
  • Sleepiness 3%
More Butisol side effects »
How it works
DoxepinButisol
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Butisol (butabarbital) is a barbiturate. It works by calming and relaxing you so you're able to sleep.
Type of medication
DoxepinButisol
Prescription onlyPrescription only
Available as
DoxepinButisol
  • Cream, gel, or ointment
  • Pill
Used for
DoxepinButisol
  • Skin Intching Moderate
Risk factors for serious side effects
DoxepinButisol
    Detailed Zonalon (doxepin) risks & warnings »
    • Having acute or chronic pain
    • age 65 or older
    • Drinking alcohol
    • Taking narcotics, tranquilizers or antihistamines
    Detailed Butisol (butabarbital) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Price
    DoxepinButisol
    • It isn't available as a generic, so it could be kind of pricey.
    No price related info.
    Interactions
    DoxepinButisol
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • Butisol (butabarbital) can interact with a lot of medicines, vitamins and supplements.
    Alcohol
    DoxepinButisol
    No alcohol related info.
    • Don't drink alcohol or take narcotics, tranquilizers or antihistamines if you're taking Butisol (butabarbital). This can slow down your breathing. Talk to your doctor about other options to help you sleep.
    • Don't drink alcohol or take narcotics with Butisol (butabarbital) since this can slow your breathing.
    Pain
    DoxepinButisol
    No pain related info.
    • If you're having acute or chronic pain, or if you're older, Butisol (butabarbital) can cause you to feel more awake instead of sleepy, or you may not notice changes in your pain until it wears off. Talk to your doctor about other options to help you sleep if this happens.
    Sleep
    DoxepinButisol
    • Zonalon (Doxepin) can make you sleepy.
    No sleep related info.
    Upsides and benefits
    DoxepinButisol
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    • Butisol (butabarbital) works very quickly to help you fall asleep, within 45-60 minutes, and it lasts 6-8 hours.
    Downsides and risks
    DoxepinButisol
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • Your body can get used to needing Butisol (butabarbital) for sleeping.
    • Butisol (butabarbital) can interact with a lot of medicines, vitamins and supplements.
    Tips from our pharmacists for people taking the medication
    DoxepinButisol
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    • Don't use Butisol (butabarbital) for more than 2 weeks, since it doesn't work as well after that.
    • Don't stop Butisol (butabarbital) suddenly, especially if you've been taking it for a while. Talk to your doctor about how to get off it safely.
    • Don't drink alcohol or take narcotics with Butisol (butabarbital) since this can slow your breathing.
    • Butisol (butabarbital) can make your birth control less effective. You should use condoms or diaphragms while taking it.
    • Talk to your doctor if Butisol (butabarbital) doesn't help you sleep better after taking it for 7 days.
    Learn more
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it
    More about ButisolSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Butisol (butabarbital)?
    Worth itNot sureNot worth it