Compare Doxepin vs. desipramine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Norpramin
(desipramine)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for desipramine
Best available price for 30 (25mg) tablets of desipramine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Side effects
Doxepindesipramine

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
How it works
Doxepindesipramine
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.
Type of medication
Doxepindesipramine
Prescription onlyPrescription only
Available as
Doxepindesipramine
  • Cream, gel, or ointment
  • Pill
Used for
Doxepindesipramine
  • Skin Intching Moderate
Risk factors for serious side effects
Doxepindesipramine
    Detailed Zonalon (doxepin) risks & warnings »
    • People under age 24
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    Detailed Norpramin (desipramine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Price
    Doxepindesipramine
    • It isn't available as a generic, so it could be kind of pricey.
    No price related info.
    Interactions
    Doxepindesipramine
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    No interactions related info.
    Sleep
    Doxepindesipramine
    • Zonalon (Doxepin) can make you sleepy.
    No sleep related info.
    Upsides and benefits
    Doxepindesipramine
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
    • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
    Downsides and risks
    Doxepindesipramine
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
    • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
    • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
    • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
    • Not recommended in children under 12 years of age.
    Tips from our pharmacists for people taking the medication
    Doxepindesipramine
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
    • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
    • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
    • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
    Learn more
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it
    More about desipramineSide effectsAlternativesFDA package insert
    Have you used Norpramin (desipramine)?
    Worth itNot sureNot worth it