Compare Doxepin vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon (Doxepin)

Prescription only

Hetlioz (tasimelteon)

Prescription only
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Keeps the sleep cycle normal for completely blind people who aren't able to see light.

Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.

Upsides
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
  • Hetlioz (tasimelteon) is not addictive.
  • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
  • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
Downsides
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
  • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
  • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
Used for
  • Skin intching (moderate)
  • Non-24 hour sleep-wake cycle
Dosage forms
  • Cream, gel, or ointment
  • Pill
Price
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$9.99
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Lowest price near you
$13611.6
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Side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
5possible side effects
  • Headache
    17%
  • Abnormal liver tests
    10%
  • Nightmares or abnormal dreams
    10%
  • Common cold or flu
    7%
  • Urinary tract infection
    7%
See more detailed side effects
Risks and warnings