Compare Doxepin vs. Hetlioz

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Hetlioz
(tasimelteon)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Keeps the sleep cycle normal for completely blind people who aren't able to see light. Hetlioz (tasimelteon) is the only approved medicine to help completely blind people who are unable to see light maintain regular sleep cycles. It is only available as a brand name, so it can be expensive.
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Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for Hetlioz
Best available price for 30 (20mg) capsules of hetlioz
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Hetlioz (tasimelteon)?
Worth itNot sureNot worth it
Side effects
DoxepinHetlioz

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »
  • Headache 10%
  • Abnormal liver tests 5%
  • Nightmares or abnormal dreams 10%
  • Common cold or flu 7%
  • Urinary tract infection 5%
More Hetlioz side effects »
How it works
DoxepinHetlioz
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Hetlioz (tasimelteon) is a melatonin receptor agonist. It helps you to sleep at night and stay awake during the day.
Type of medication
DoxepinHetlioz
Prescription onlyPrescription only
Available as
DoxepinHetlioz
  • Cream, gel, or ointment
  • Pill
Used for
DoxepinHetlioz
  • Skin Intching Moderate
  • Non 24 Hour Sleep Wake Cycle
Risk factors for serious side effects
DoxepinHetlioz
    Detailed Zonalon (doxepin) risks & warnings »
      Detailed Hetlioz (tasimelteon) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Price
      DoxepinHetlioz
      • It isn't available as a generic, so it could be kind of pricey.
      No price related info.
      Interactions
      DoxepinHetlioz
      • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
      No interactions related info.
      Sleep
      DoxepinHetlioz
      • Zonalon (Doxepin) can make you sleepy.
      • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
      Upsides and benefits
      DoxepinHetlioz
      • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
      • You can use Zonalon (Doxepin) for up to 8 days at a time.
      • Hetlioz (tasimelteon) is not addictive.
      • Hetlioz (tasimelteon) is the only drug that's approved to help people unable to see light to have regular sleep cycles.
      • If you have to stop taking Hetlioz (tasimelteon) suddenly, you're not likely to have withdrawal.
      Downsides and risks
      DoxepinHetlioz
      • You need a prescription for Zonalon (Doxepin).
      • It isn't available as a generic, so it could be kind of pricey.
      • Zonalon (Doxepin) can make you sleepy.
      • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
      • Hetlioz (tasimelteon) can take weeks to months for you to notice any effect.
      • Hetlioz (tasimelteon) is only available as a brand name so it can be expensive.
      Tips from our pharmacists for people taking the medication
      DoxepinHetlioz
      • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
      • Wash your hands before and after using it.
      • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
      • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
      • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
      • Take Hetlioz (tasimelteon) at the same time every night.
      • Take Hetlioz (tasimelteon) on an empty stomach. Swallow capsule whole. Don't crush or chew the capsule.
      • If you go to sleep at a different time, don't take Hetlioz (tasimelteon).
      • Hetlioz (tasimelteon) might take weeks or months before you notice any effects.
      • If you smoke tobacco, Hetlioz (tasimelteon) might not work as well.
      Learn more
      More about DoxepinSide effectsFDA package insert
      Have you used Zonalon (doxepin)?
      Worth itNot sureNot worth it
      More about HetliozSide effectsFDA package insert
      Have you used Hetlioz (tasimelteon)?
      Worth itNot sureNot worth it