Compare Doxepin vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Pamelor
(nortriptyline)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
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Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for Pamelor
Best available price for 30 (10mg) capsules of nortriptyline
Reviews & ratings
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Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it
Reviews for Pamelor
79%
-79% worse vs. Doxepin
79%
-79% worse vs. Doxepin
21%
+21% better vs. Doxepin
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Side effects
DoxepinPamelor

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
DoxepinPamelor
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
DoxepinPamelor
Prescription onlyPrescription only
Available as
DoxepinPamelor
  • Cream, gel, or ointment
  • Pill
  • Liquid
Used for
DoxepinPamelor
  • Skin Intching Moderate
Risk factors for serious side effects
DoxepinPamelor
    Detailed Zonalon (doxepin) risks & warnings »
    • Age 24 years or younger
    • Age 65 years or older
    • Stopping Pamelor (Nortriptyline) suddenly
    • Using other medications that affect serotonin
    • History of heart disease
    Detailed Pamelor (nortriptyline) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Price
    DoxepinPamelor
    • It isn't available as a generic, so it could be kind of pricey.
    No price related info.
    Interactions
    DoxepinPamelor
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    No interactions related info.
    Food
    DoxepinPamelor
    No food related info.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    Sleep
    DoxepinPamelor
    • Zonalon (Doxepin) can make you sleepy.
    No sleep related info.
    Upsides and benefits
    DoxepinPamelor
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    • Helpful with treating certain types of pain, like migraines or nerve-related pain.
    • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
    Downsides and risks
    DoxepinPamelor
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • Side effects are usually manageable, but can be annoying.
    • Increases the risk of falls, especially when used in the elderly.
    • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
    Tips from our pharmacists for people taking the medication
    DoxepinPamelor
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
    • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    Learn more
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it
    More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Pamelor (nortriptyline)?
    Worth itNot sureNot worth it