Compare Doxepin vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon (Doxepin)

Prescription only

Surmontil (trimipramine)

Prescription only
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Improves your mood.

Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.

Upsides
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Used for
  • Skin intching (moderate)
Dosage forms
  • Cream, gel, or ointment
  • Pill
Price
Lowest price near you
$9.99
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Lowest price near you
$99.6
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Reviews
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Side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
The Surmontil (trimipramine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
See more detailed risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 6 more risk factors

  • Heart problems

    History of heart disease

See more detailed risks and warnings