Compare Doxepin vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Surmontil
(trimipramine)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
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Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for Surmontil
Best available price for 30 (100mg) capsules of surmontil
Reviews & ratings
Filter group. All currently selected
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects
DoxepinSurmontil

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
DoxepinSurmontil
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
DoxepinSurmontil
Prescription onlyPrescription only
Available as
DoxepinSurmontil
  • Cream, gel, or ointment
  • Pill
Used for
DoxepinSurmontil
  • Skin Intching Moderate
Risk factors for serious side effects
DoxepinSurmontil
    Detailed Zonalon (doxepin) risks & warnings »
    • People under age 24
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    Detailed Surmontil (trimipramine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Price
    DoxepinSurmontil
    • It isn't available as a generic, so it could be kind of pricey.
    No price related info.
    Interactions
    DoxepinSurmontil
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    No interactions related info.
    Food
    DoxepinSurmontil
    No food related info.
    • Can be taken with or without food.
    Sleep
    DoxepinSurmontil
    • Zonalon (Doxepin) can make you sleepy.
    No sleep related info.
    Upsides and benefits
    DoxepinSurmontil
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
    • Available in generic and in three different strengths.
    • Can be taken once a day, usually before you go to bed.
    • Can be taken with or without food.
    Downsides and risks
    DoxepinSurmontil
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
    • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
    • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
    Tips from our pharmacists for people taking the medication
    DoxepinSurmontil
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
    • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
    • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
    Learn more
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it
    More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Surmontil (trimipramine)?
    Worth itNot sureNot worth it