Compare Doxepin vs. Vivactil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon
(doxepin)

Vivactil
(protriptyline)

Helps you stop itching. Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.Improves your mood. Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.
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Coupons for Doxepin
Best available price for 30 (10mg) capsules of doxepin
Coupons for Vivactil
Best available price for 60 (5mg) tablets of vivactil
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Zonalon (doxepin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Vivactil (protriptyline)?
Worth itNot sureNot worth it
Side effects
DoxepinVivactil

We haven’t found good data for Doxepin side effects.

FDA side effect reports for Doxepin »

The Vivactil FDA package insert doesn’t have numbers about how common side effects are.

More about Vivactil side effects »
How it works
DoxepinVivactil
Zonalon (Doxepin) is an cream that stops you from itching by blocking the chemical receptors that cause itching.Vivactil (protriptyline) is a tricyclic antidepressant. It regulates mood by raising the amount of serotonin and norepinephrine in the brain.
Type of medication
DoxepinVivactil
Prescription onlyPrescription only
Available as
DoxepinVivactil
  • Cream, gel, or ointment
  • Pill
Used for
DoxepinVivactil
  • Skin Intching Moderate
Risk factors for serious side effects
DoxepinVivactil
    Detailed Zonalon (doxepin) risks & warnings »
    • Under age 24
    • History of heart disease
    • Overactive thyroid
    • History of seizures
    • High blood pressure
    Detailed Vivactil (protriptyline) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Price
    DoxepinVivactil
    • It isn't available as a generic, so it could be kind of pricey.
    No price related info.
    Interactions
    DoxepinVivactil
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    No interactions related info.
    Sleep
    DoxepinVivactil
    • Zonalon (Doxepin) can make you sleepy.
    No sleep related info.
    Upsides and benefits
    DoxepinVivactil
    • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
    • You can use Zonalon (Doxepin) for up to 8 days at a time.
    • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
    • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
    • Available in generic.
    Downsides and risks
    DoxepinVivactil
    • You need a prescription for Zonalon (Doxepin).
    • It isn't available as a generic, so it could be kind of pricey.
    • Zonalon (Doxepin) can make you sleepy.
    • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
    • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
    • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
    • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
    Tips from our pharmacists for people taking the medication
    DoxepinVivactil
    • Be sure the affected area is clean and dry before applying Zonalon (Doxepin).
    • Wash your hands before and after using it.
    • Apply a thin layer of Zonalon (Doxepin) onto the affected area and rub it in gently.
    • Don’t put a bandage, dressing, or make-up over Zonalon (Doxepin) once it's on your skin.
    • It shouldn't affect you too much, but avoid activities that need you to be fully alert (like driving) until you know how it works.
    • Take Vivactil (protriptyline) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
    • You might have to take Vivactil (protriptyline) for a few weeks before you notice any changes in your mood.
    • Vivactil (protriptyline) can make you more sensitive to the sun. Wear sunscreen or cover your skin if you're going to be out in the sun for a while.
    • Don't stop taking Vivactil (protriptyline) without talking to your doctor first.
    • Be very careful getting up if you've been sitting or lying down for a while since Vivactil (protriptyline) can make you feel dizzy.
    Learn more
    More about DoxepinSide effectsFDA package insert
    Have you used Zonalon (doxepin)?
    Worth itNot sureNot worth it
    More about VivactilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Vivactil (protriptyline)?
    Worth itNot sureNot worth it