Compare Doxepin vs. Vivactil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Zonalon (Doxepin)

Prescription only

Vivactil (protriptyline)

Prescription only
Helps you stop itching.

Zonalon (Doxepin) works well treating itchy skin, but could make you sleepy.

Improves your mood.

Vivactil (protriptyline) is part of the first choice of medicines for depression, but it can cause problems with your heartbeat and change your sex drive.

Upsides
  • In clinical trials, Zonalon (Doxepin) was found to be the most effective cream for treating itchy skin.
  • You can use Zonalon (Doxepin) for up to 8 days at a time.
  • Vivactil (protriptyline) is part of the first choice medicines for treating depression.
  • Compared to similar medicines, Vivactil (protriptyline) is less likely to make you feel sleepy.
  • Available in generic.
Downsides
  • You need a prescription for Zonalon (Doxepin).
  • It isn't available as a generic, so it could be kind of pricey.
  • Zonalon (Doxepin) can make you sleepy.
  • Zonalon (Doxepin) can interact with other medications, vitamins, or alternative treatments.
  • Vivactil (protriptyline) can lower your sex drive more than some other similar medicines.
  • Because Vivactil (protriptyline) can cause dizziness, people age 65 and older need to take precautions when taking Vivactil (protriptyline).
  • Vivactil (protriptyline) can worsen heart conditions. If you have a history of heart problems, you may need to have regular testing for your heart.
Used for
  • Skin intching (moderate)
Dosage forms
  • Cream, gel, or ointment
  • Pill
Price
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$9.99
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Lowest price near you
$32.78
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Reviews
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Side effects
The Zonalon (Doxepin) FDA package insert doesn’t have numbers about how common side effects are.
The Vivactil (protriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
See more detailed risks and warnings
  • Higher risk of suicide

    Under age 24

  • Heart problems

    History of heart disease

    ...and 1 more risk factors

  • Higher risk of seizures

    History of seizures

  • Changes in blood pressure

    High blood pressure

See more detailed risks and warnings