Compare Doxycycline vs. Augmentin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(doxycycline)

Augmentin
(amoxicillin / clavulanate)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Treats bacterial infections. Augmentin (amoxicillin / clavulanate) is first-choice antibiotic for most common types of infections. However, it may not work against more serious or uncommon types of infections.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Doxycycline
Reviews for Vibramycin (doxycycline)
49%
of people (All ages) say Vibramycin (doxycycline) is worth it
36%
say it works well
24%
say it's a big hassle
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Augmentin (amoxicillin / clavulanate)
68%
+19% better vs. Vibramycin (doxycycline)
52%
+16% better vs. Vibramycin (doxycycline)
13%
+11% better vs. Vibramycin (doxycycline)
1034 reviews
Have you used Augmentin (amoxicillin / clavulanate)?
Worth itNot sureNot worth it
Side effects
DoxycyclineAugmentin
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »
  • Diarrhea 9%
  • Nausea 3%
  • Skin rash and hives 3%
More Augmentin side effects »
How it works
DoxycyclineAugmentin
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Augmentin (amoxicillin / clavulanate) contains two antibiotic medicines, which kill bacteria.
Type of medication
DoxycyclineAugmentin
Prescription only
Prescription only
Available as
DoxycyclineAugmentin
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
Used for
DoxycyclineAugmentin
Risk factors for serious side effects
DoxycyclineAugmentin
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (doxycycline) risks & warnings »
      • History of penicillin allergies
        • Taking Augmentin (amoxicillin / clavulanate) for a long time
        • Mononucleosis
        • Using oral birth control pills
        Detailed Augmentin (amoxicillin / clavulanate) risks & warnings »
        Pregnancy

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Food
        DoxycyclineAugmentin
        No food related info.
        • Take with food if you're having upset stomach.
        Kidneys and liver
        DoxycyclineAugmentin
        No kidneys and liver related info.
        • Liver damage has been associated with patients taking Augmentin (amoxicillin / clavulanate). It's usually reversible, but deaths have been reported. Talk to your doctor if you notice pain in your abdomen, loss of appetite, yellowing of your skin or eyes, or dark colored urine.
        Upsides and benefits
        DoxycyclineAugmentin
        • Available in generic.
        • Available in different forms: tablet, capsule, and suspension.
        • Used to treat many types of bacterial infections.
        • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
        • Available as generic product.
        • Available in tablet, capsule, and liquid forms.
        • Used to treat most common types of bacterial infections.
        • Side effects are generally not too bad compared to other antibiotics.
        Downsides and risks
        DoxycyclineAugmentin
        • Can't be used in pregnant women and children under 8 years old.
        • Makes your skin more sensitive to the sun.
        • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
        • Can make birth control less effective.
        • Can cause diarrhea.
        • Many bacteria have developed resistance to this antibiotic.
        • Can cause diarrhea, nausea, and vomiting.
        • Birth control pills may not work as well to prevent pregnancy when taking this medication.
        Tips from our pharmacists for people taking the medication
        DoxycyclineAugmentin
        • Take the medication exactly how your doctor tells you to.
        • If you're using birth control pills, this medication can make them less effective.
        • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
        • Can cause diarrhea, nausea or vomiting.
        • Space out any vitamins by at least two hours.
        • Take with plenty of food and liquids.
        • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
        • Don't lie down for at least 30 minutes after taking this medication.
        • Finish all of your medicine even if you start to feel better. Stopping it early can cause the infection to come back stronger than before.
        • Can make your oral birth control less effective. Consult your doctor or pharmacist if you need to use backup.
        • Take with food if you're having upset stomach.
        • Store the liquid in the fridge and throw away after 10 days.
        • Shake the suspension thoroughly before using each dose.
        Learn more
        More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Vibramycin (doxycycline)?
        Worth itNot sureNot worth it
        More about AugmentinSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Augmentin (amoxicillin / clavulanate)?
        Worth itNot sureNot worth it