Compare doxycycline vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats bacterial infections.

Vibramycin (doxycycline) is good for treating many bacterial infections, but can increase your skin's sensitivity to sunlight and make you more likely to get a sunburn or rash.

3.2/ 5 average rating with 112 reviewsfordoxycycline
Kills bacteria.

Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.

3.6/ 5 average rating with 473 reviewsforBactrim
Upsides
  • Vibramycin (doxycycline) is a good alternative for some types of bacterial infections for people who are allergic to penicillin.
  • Available in generic.
  • Available as a liquid for those who have trouble swallowing.
  • Vibramycin (doxycycline) is safe for people age 65 or older and those who have kidney problems.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
Downsides
  • Vibramycin (doxycycline) makes your skin more sensitive to the sun.
  • Vibramycin (doxycycline) can make some birth control less effective, so you may have to use barrier methods (like condoms) while on it.
  • Vitamins, iron supplements, or antacids can't be taken at the same time as Vibramycin (doxycycline).
  • Vibramycin (doxycycline) can cause severe diarrhea that is usually watery and bloody, as late as up to 2 months after finishing the medicine.
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
Used for
Dosage forms
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Liquid
Price
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Reviews
112 reviews so far
49%
saidit'sworth it
36%
saiditworked well
24%
saidit'sa big hassle

Have you used Vibramycin (doxycycline)?

Leave a review
473 reviews so far
59%
saidit'sworth it
49%
saiditworked well
22%
saidit'sa big hassle

Have you used Bactrim (sulfamethoxazole / trimethoprim)?

Leave a review
Side effects
The Vibramycin (doxycycline) FDA package insert doesn’t have numbers about how common side effects are.
The Bactrim (sulfamethoxazole / trimethoprim) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Color changes in teeth of young children and unborn babies
    • Age 8 or younger
    • Women in their last half of pregnancy
    • Infants
  • Severe diarrhea
    • Using Vibramycin (doxycycline) for a long period of time
  • Sunburn or rash
    • Being in the sun for a long period of time
    • Using tanning salons
  • Harm to fetus (unborn baby)
    • Women who can potentially or want to become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Diarrhea
  • Sunburn
  • Rash
  • Harm to fetus
  • Lower kidney function
    • Elderly
    • Taking other medicines that lower kidney function
See more detailed risks and warnings