Compare Doxycycline vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(Doxycycline)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.223300970873787Doxycycline
Reviews for Vibramycin (Doxycycline)
50%
of people say Vibramycin (Doxycycline) is worth it
34%
say it works well
23%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
+9% vs. Vibramycin (Doxycycline)
50%
+16% vs. Vibramycin (Doxycycline)
22%
+1% vs. Vibramycin (Doxycycline)
Side effects
DoxycyclineBactrim

The Doxycycline FDA package insert doesn’t have numbers about how common side effects are.

More about Doxycycline side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
DoxycyclineBactrim
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
DoxycyclineBactrim
Antibiotic
Tetracycline
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
DoxycyclineBactrim
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Used for (click to learn more)
DoxycyclineBactrim
Risk factors for serious side effects
DoxycyclineBactrim
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
      • Women of childbearing age
      • Women of childbearing age
      • Overweight or obese
      • Taking isotretinoin (Accutane)
      Detailed Vibramycin (Doxycycline) risks & warnings »
              Detailed Bactrim (Sulfamethoxazole / Trimethoprim) risks & warnings »
              Pregnancy category
              DoxycyclineBactrim
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
              • Take with plenty of food and liquids.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              DoxycyclineBactrim
              • Available in different forms: tablet, capsule, and suspension.
              • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
              • Available in generic.
              • Used to treat many types of bacterial infections.
              • Available in different forms: tablet, capsule and suspension.
              • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
              • Available in generic.
              • Used to treat many types of bacterial infections.
              Downsides and risks
              DoxycyclineBactrim
              • Can't be used in pregnant women and children under 8 years old.
              • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
              • Can make birth control less effective.
              • Makes your skin more sensitive to the sun.
              • Can cause diarrhea.
              • Has to be taken with plenty of liquids.
              • May cause birth defects.
              • Makes your skin more sensitive to the sun.
              • Can cause diarrhea.
              Tips from our pharmacists for people taking the medication
              DoxycyclineBactrim
              • Take the medication exactly how your doctor tells you to.
              • If you're using birth control pills, this medication can make them less effective.
              • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
              • Space out any vitamins by at least two hours.
              • Take with plenty of food and liquids.
              • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
              • Don't lie down for at least 30 minutes after taking this medication.
              • Can cause diarrhea, nausea or vomiting.
              • Take this medication exactly how your doctor tells you to.
              • Can make your skin more sensitive to the sun.
              • Drink plenty of liquids when taking the medication.
              • Can cause rash.
              • Can cause diarrhea, nausea or vomiting.
              Learn more
              More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
              More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert