Compare Doxycycline vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Vibramycin
(doxycycline)

Bactrim
(sulfamethoxazole / trimethoprim)

Treats bacterial infections. Vibramycin (Doxycycline) is good for treating many bacterial infections. It is also available as generic. However, it can make birth control pills less effective. You also have to protect yourself against sunburn.Kills bacteria. Bactrim (sulfamethoxazole / trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn.
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Coupons for Bactrim
Best available price for 20 (800mg/160mg) tablets of sulfamethoxazole / trimethoprim
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.27Doxycycline
Reviews for Vibramycin (doxycycline)
49%
of people (All ages) say Vibramycin (doxycycline) is worth it
36%
say it works well
24%
say it's a big hassle
112 reviews
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
Reviews for Bactrim (sulfamethoxazole / trimethoprim)
59%
+10% better vs. Vibramycin (doxycycline)
49%
+13% better vs. Vibramycin (doxycycline)
22%
+2% better vs. Vibramycin (doxycycline)
473 reviews
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it
Side effects
DoxycyclineBactrim
  • Any adverse event 40%
  • Nausea 13%
  • Vomiting 8%
  • Diarrhea 3%
  • Bacterial vaginitis 3%
  • Headache 2%
  • Upper abdominal pain 2%
  • Vaginal yeast infection 2%
More Doxycycline side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
DoxycyclineBactrim
Vibramycin (Doxycycline) is a tetracycline antibiotic. It stops bacteria by preventing them from reproducing and repairing themselves.Bactrim (sulfamethoxazole / trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria.
Type of medication
DoxycyclineBactrim
Prescription only
Prescription only
Available as
DoxycyclineBactrim
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Liquid
Used for
DoxycyclineBactrim
Risk factors for serious side effects
DoxycyclineBactrim
  • Age 8 years or younger
  • Using oral birth control pills
  • Long antibiotic treatment period
  • Women of childbearing age
Detailed Vibramycin (doxycycline) risks & warnings »
  • Elderly
  • Taking other medicines that lower kidney function
Detailed Bactrim (sulfamethoxazole / trimethoprim) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
DoxycyclineBactrim
No kidneys and liver related info.
  • Bactrim (sulfamethoxazole / trimethoprim) can harm your kidneys, especially if you're taking anti-inflammatory pain relievers like Motrin or Advil or other medicines that also affect your kidneys. Make sure to drink plenty of water or fluids while you're taking Bactrim (sulfamethoxazole / trimethoprim).
Upsides and benefits
DoxycyclineBactrim
  • Available in generic.
  • Available in different forms: tablet, capsule, and suspension.
  • Used to treat many types of bacterial infections.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Widely available as a generic product and in a variety of formulations (tablet, capsule, suspension).
  • Works well to treat many types of bacterial infections
Downsides and risks
DoxycyclineBactrim
  • Can't be used in pregnant women and children under 8 years old.
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of water and food and you have to stay upright for 30 minutes afterwards to avoid stomach irritation.
  • Can make birth control less effective.
  • Can cause diarrhea.
  • Makes you sensitive to the sun.
  • Can upset your stomach
  • Drink plenty of water or fluids to avoid harming your kidneys
  • May cause birth defects
Tips from our pharmacists for people taking the medication
DoxycyclineBactrim
  • Take the medication exactly how your doctor tells you to.
  • If you're using birth control pills, this medication can make them less effective.
  • Wear sunblock if you have to go out into the sun since your skin can become more sensitive to sunburn.
  • Can cause diarrhea, nausea or vomiting.
  • Space out any vitamins by at least two hours.
  • Take with plenty of food and liquids.
  • Don't take any medications with bismuth (Pepto-Bismol, Kaopectate) while taking this medication.
  • Don't lie down for at least 30 minutes after taking this medication.
  • Take Bactrim (sulfamethoxazole / trimethoprim) exactly the way your doctor tells you.
  • Can make you more sensitive to the sun. Keep out of the sun or wear protection while under the sun.
  • Drink plenty of water or liquids while on Bactrim (sulfamethoxazole / trimethoprim) to avoid harming your kidneys.
  • Can cause upset stomach.
  • Can cause an allergic reaction. Talk to your doctor if you notice skin rash or swelling of your face.
Learn more
More about DoxycyclineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vibramycin (doxycycline)?
Worth itNot sureNot worth it
More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Bactrim (sulfamethoxazole / trimethoprim)?
Worth itNot sureNot worth it